このエントリーをはてなブックマークに追加
ID 21215
Eprint ID
21215
FullText URL
Title Alternative
Studies on lithium in the field of balneology : Effects of lithium salts on analgesic activity of aminopyrine
Author
Furuno, Katsushi
Mifune, Masaaki
Abstract
The authors studied the effect of pretreatment with internal use of lithium salts on analgesic activity of aminopyrine by hot-plate test in mice. The male mice at 4 weeks of age weighting 17-19 g were divided into 7 groups. Earch group being composed of 9-10 mice was given oraBy 0.1 ml of LiCI-solution per 10 g of body weight for 35 days, LiCl was dissolved in 0.9% saline solution, in such concentrations that each group received 0 mg, 50 mg, 100mg, 200 mg and 400mg of LiCl for each kg of body weight of mouse, respectively, Control group received only 0.9% saline solution. On the 1st, 3rd, 7th, 14th, 21st, 28th and 35th days of this experiment, 0.1 ml of 1% solution of aminopyrine per 109 of body weight was injected intraperitoneaJly and then tested 30 minutes later. In the hot-plate test, a mouse is placed on a hot plate being adjusted with the thermostat at 55°±1℃, and the response is licking or lifting the hind feet or an outright attempt to escape from the plate, The increase in response time is used to quantify the analgesic effect of aminopyrine, The results were as follows : 1. The response time in groups receiving 0-50 mg of LiCl per kg of body weight had decreased on the 14 th day, but it tended to return to the initial level after the 21st day of experiment. 2. The response time in groups receiving 100-400 mg of LiCl per kg of body weight had also decreased on the 14 th day, and the degree of the decrease in response time was greater than that of the former and then remained faily constant at this level to the end of the observation period. These results would indicate that LiCl inhibits the analgesic activity of aminopyrine.
Note
原著論文 (Original Papers)
Published Date
1976-03-25
Publication Title
岡山大学温泉研究所報告
Publication Title Alternative
Papers of the Institute for Thermal Spring Research, Okayama University
Volume
volume45
Publisher
岡山大学温泉研究所
Publisher Alternative
Institute for Thermal Spring Research, Okayama University
Start Page
25
End Page
31
ISSN
0369-7142
NCID
AN00032853
Content Type
Departmental Bulletin Paper
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
mmc