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ID 40654
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Title Alternative
Antithrombotic therapy after heart valve replacement - Especially on the clinical effect of antithrombogenic drugs -
Author
Kojo, Masayoshi
Abstract
To evaluate the effect of antithrombotic therapy, serial changes in platelet aggregability were investigated in 103 patients who had received heart valve replacement. All patients received warfarin and were divided into three groups: warfarin alone (control), and combined with trapidil and dipyridamole. Both antithrombogenic drugs were given at a dose of 300 mg/day. Platelet count and aggregation were evaluated out every three months for 36 months. Antiplatelet drugs had no affect on the platelet count during the course. The platelet aggregation did not change in the control group, but were decreased at 24 and 30 months in the trapidil group and 24 months in the dipyridamole group. The platelet aggregation was significantly suppressed by trapidil compared to the control at 30 months. The incidence of thromboembolism in control, trapidil and dipyridamole groups was 9.0%, 4.3% and 7.7% respectively. These results indicate that anti-platelet drugs given with warfarin are safe and effective for patients with a prosthetic valve to prevent thromboembolism.
Keywords
人工弁置換術
血栓塞栓症
抗血栓療法
血小板凝集抑制剤
Published Date
1990-08
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume102
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
831
End Page
841
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/102/7-8/102_7-8_831/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma