岡山医学会 Acta Medica Okayama 0030-1558 79 3-4 1967 肝疾患時に見られる肝の脂肪沈着とGlucose Tolerance Test時の血中非エステル型脂肪酸の変動について 第2編 353 357 EN Yutaka Komoto The changes of serum NEFA concentration after oral glucose administration were examined in patients with acute hepatitis (convalescent), chronic hepatitis, liver cirrhosis and fatty liver, excluding obesity, manifest arteriosclerotic vascular disorders, diabetes and other endocrine disorders. 1) The fasting NEFA value had the tendency to increase in liver diseases, especially in liver cirrhosis. No correlation was found between the NEFA value and the extent of hepatic fatty infiltration. 2) Although no specific pattern of NEFA response to glucose was found in these liver diseases, the decrease in NEFA concentration following the glucose load became less marked in accordance with the increase in the extent of hepatic fatty infiltration. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 79 3-4 1967 肝疾患における肝Glucose-6-phosphate dehydrogenase, 6- Phosphogluconate dehydrogenaseおよびCitrate cleavage enzyme活性と肝の脂肪沈着について 第1編 347 351 EN Yutaka Komoto The activities of Glucose-6-phosphate dehydrogenase, 6-Phosphogluconate dehydrogenase and Citrate cleavage enzyme, of which increase is known to be associated with an enhanced lipogenesis in experimental animals, were measured in the liver tissues from the patients with liver diseases. 1) The activities of these enzymes were significantly increased in the convalescent stage of acute hepatitis, while no significant changes were found in chronic hepatitis (active or inactive), liver cirrhosis and fatty liver. 2) No apparent correlation was found between the activities of these enzymes and the degree of hepatic fatty infiltration in these liver diseases, suggesting that hepatic lipogenesis might not play a majar role in fatty change of liver encountered in the course of the liver diseases. Alternatively, the increased enzyme activities might reflect some other metabolic alterations associated with hepatic injury. No potential conflict of interest relevant to this article was reported.