JaLCDOI 10.18926/AMO/32003
FullText URL fulltext.pdf
Author Yoshida, Yasuhiro| Higashi, Toshihiro| Nouso, Kazuhiro| Nakatsukasa, Harushige| Nakamura, Shin-ichiro| Watanabe, Akiharu| Tsuji, Takao|
Abstract <p>Hepatic encephalopathy is one of the major complications in decompensated liver cirrhosis. The current study was conducted to clarify the mechanisms of zinc deficiency in liver cirrhosis and its involvement in hepatic encephalopathy via ammonia metabolism. Ten patients each with compensated or decompensated liver cirrhosis and 11 healthy volunteers were enrolled in the study. Serum zinc levels and its daily urinary excretion were measured, an oral zinc-tolerance test was performed to examine zinc malabsorption, and the effects of diuretics on zinc excretion and of zinc supplementation on ammonia metabolism in the skeletal muscle were studied. The mean serum zinc levels in patients with decompensated liver cirrhosis were found to be significantly lower than the levels in controls and patients with compensated liver cirrhosis. The serum zinc levels were inversely correlated with blood ammonia in the fasting state. In the oral zinc-tolerance test, the percent increase in serum zinc levels 120 and 180 min after ingestion was less in cirrhotic patients than in controls. A diuretic administration resulted in a significant reduction in serum zinc levels. An increased uptake of ammonia by and an increased release of glutamine from leg skeletal muscle after oral supplementation of zinc sulfate were evident. Taken together, zinc deficiency in decompensated cirrhotic patients appears to be due to low absorption and to high urinary excretion, for which excessive diuretic administration is, in part, responsible, and zinc supplementation might play an important role in the prevention of hepatic encephalopathy by activating glutamine synthetase.</p>
Keywords zinc ammonia liver cirrhosis hepatic encephalopathy
Amo Type Article
Published Date 2001-12
Publication Title Acta Medica Okayama
Volume volume55
Issue issue6
Publisher Okayama University Medical School
Start Page 349
End Page 355
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11779097
Web of Science KeyUT 000172838400005
Author Kadowaki, Emiko| Yoshida, Yasuhiro| Baba, Naomichi| Nakajima, Shuhei|
Published Date 2003-02
Publication Title 岡山大学農学部学術報告
Volume volume92
Issue issue1
Content Type Departmental Bulletin Paper