JaLCDOI 10.18926/21084
Title Alternative Spa therapy for patients with chronic obstructive lung disease
FullText URL pitsr_056_023_026.pdf
Author Sudo, Michiyasu| Komagoe, Haruki| Tanizaki, Yoshiro| Morinaga, Hiroshi|
Abstract During last three years, 41 patients with chronic obstructive lung disease (39 cases with bronchial asthma and 2 cases with chronic bronchiolitis) received spa therapy at Department of Medicine, Okayama University Medical School, Misasa Medical Branch. 1. Twenty three (56%) out of 41 cases came from Okayama prefecture and 10 cases (24.4%) from Tottori prefecture for spa therapy. In twenty five (61.0%) out of 41 cases, their ages were over 50 years. 2. Thirty nine patients with bronchial asthma were divided into three asthma types classified by clinical symptoms : Ia ; 16 cases (41.0%), Ib; 13 cases (33.3%) and II ; 10 cases (25.7%). Pulmonary function tests for these patients showed that small airways obstruction was most remarkable in type II asthma. 3. The mean serum IgE level of all asthmatic patients (39 cases) was 653.9U/ml. In skin test by allergens, positive immediate skin reaction was shown in 18 cases (46.2%) by Candida and 12 cases (30.8%) by house dust. Specific IgE anti-bodies were found in 9 cases (23.1%) for house dust and 3 cases (7.7%) for Candida.
Publication Title 岡山大学温泉研究所報告
Published Date 1985-03-30
Volume volume56
Start Page 23
End Page 26
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002311025
JaLCDOI 10.18926/19842
Title Alternative ステロイド依存性重症難治性喘息に対する温泉療法の遠隔効果
FullText URL 061_001_006.pdf
Author Tanazaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Okuda, Hiroyuki| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract The immediate effects (IEs) and distant effects (DEs) of spa therapy were observed in 67 patients with steroid- dependent intractable asthma (SDIA). (1) The IEs of spa therapy evaluated one week after spa therapy were considerably high, and the efficacy rate was 61.5% in type Ⅰa, 82.7% in type Ⅰb, and 83.4% in type Ⅱ asthmatics. (2) The DEs of spa therapy on SDIA were also observed. The efficacy rate was 50.2% in type Ⅰa, 54.3% in type Ⅰb and 63.7% in type Ⅱ asthmatics. (3) The DEs of spa therapy were different between cases with and without maintenance therapy (MT). The efficacy rate of DEs was generally high (72.8~91.7%) in cases with MT, and low (16.7~40.0%) in cases without MT. These results show that MT is very important to keep the IEs of spa therapy high for a long time.
Abstract Alternative 67例のステロイド依存性重症難治性喘息を対象に,温泉療法を行い,その即時的効果(1週間後)および遠隔効果(1年後),さらには,温泉療法後の継続療法の影響などについて検討を加えた。1.温泉療法1週間後の即時的効果は比較的高く,その有効率は,Ⅰa.気管支攣縮型で61.5%,Ⅰb.気管支攣縮+過分泌型で82.7%,Ⅱ.細気管支閉塞型で83.4%であった。2.温泉療法の遠隔効果では,その有効率は,Ⅰa型で50.2%,Ⅰb型で54.1%,Ⅱ型で63.7%であった。3.温泉療法の遠隔効果は,その後の継続療法の有無によりかなり異なった結果であった。すなわち,継続療法を行った症例の有効率は,72.8~91.7%と高く,一方,継続療法を行わなかった症例の有効率は,16.7~40.0%の間にあった。これらの結果から,温泉療法の即時的効果を保つためには,その後の継続療法が極めて重要であることが示唆された。
Keywords lmmediate effects (即時的効果) Distant effects (遠隔効果) Maintenance therapy (継続療法) Spa therapy (温泉療法) Steroid-dependent intractable asthma (ステロイド依存性重症難治性喘息)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 1
End Page 6
ISSN 09133771
language 英語
File Version publisher
NAID 120002309169
Author Matsubara, Fumie| Endo, Hiroi| Sudo, Michiyasu| Tanizaki, Yoshiro|
Published Date 1989-07
Publication Title 環境病態研報告
Volume volume60
Content Type Data or Dataset
JaLCDOI 10.18926/19808
Title Alternative Clinical studies on serum cortisol levels in patients with intractable asthma
FullText URL 060_061_066.pdf
Author Araki, Hiroyuki| Kitani, Hikaru| Sudo, Michiyasu| Tanizaki, Yoshiro| Tada, Sinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 重症難治性喘息におけるステロイド剤の副腎皮質機能,免疫能に及ぼす影響を調べるため,喘息患者65例を過去3年間のステロイド剤使用状況により,Ⅰ群:依存性症例,Ⅱ群:時に使用する症例,Ⅲ群:非使用例の3群に分け,血清コルチゾール値,末梢血リンパ球数及び血清免疫グロブリンについて検討した。結果は,血清コルチゾール値:Ⅰ群4.0μg/dℓ,Ⅲ群11.6μg/dℓ,末梢血リンパ球数:Ⅰ群1,659/mm(3)Ⅲ群2,150/mm(3),I gG:Ⅰ群1,062mg/dℓ,Ⅲ群1.501mg/dℓ,IgA:Ⅰ群218mg/dℓ,Ⅲ群279mg/dℓ,IgM:Ⅰ群148mg/dℓ,Ⅲ群227mg/dℓとⅠ群はⅢ群に比べ有意に低い平均値を示しステロイド剤の副腎皮質機能,免疫能への抑制作用が窺われた。また末梢血リンパ球数の減少は,高齢者のステロイド依存性例に顕著であった。
Abstract Alternative In order to investigate adverse effects of steroid therapy on adrenocortical function and immune function, serum cortisol levels, peripheral lymphocytes' counts and serum immuno-globulin levels were examined in 65 asthmatic patients. The asthmatic patients were classified into 3 groups according to steroid therapy for the past 3 years ; group Ⅰ has been treated with continuous steroid therapy, group Ⅱ with occasional steroid therapy and group Ⅲ without steroid therapy. The results were as follows. 1. The mean of serum cortisol levels was lower significantly in group Ⅰ as compared with that in group Ⅲ, (groupⅠ:4.0μg/dℓ, groupⅢ:11.6μg/dℓ). 2. The average count of peripheral lymphocytes was more decreased in group Ⅰ than in group Ⅲ. The difference between the two groups was significantly, (group Ⅰ:1659/mm(3), group Ⅲ:2150/mm(3)). 3. The average levels of serum immunoglobinlins such as IgG, IgA and IgM was  significantly lower in group Ⅰ compared with that in group Ⅲ, (group Ⅰ :IgG 1062mg/dℓ, IgA 218mg/dℓ, IgM 148mg/dℓ, group Ⅲ: IgG 1501mg/dℓ, IgA 279mg/de, IgM 227mg/dℓ). The results suggested that long-tetm steroid therapy remarkably suppressed adrenocortical function and immune function in patients with asthma.
Keywords 重症難治性喘息 (Intractable asthma) 血清コルチゾール (Serum cortisol) 末梢血リンパ球 (Peripheral lymphocytes) 血清免疫グロブリン (Serum immunoglobuiin)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 61
End Page 66
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309108
JaLCDOI 10.18926/19805
Title Alternative Clinical studies on bronchial asthma induced by chironomid midges -comparison between positive and negative cases to house dust-
FullText URL 060_054_060.pdf
Author Kitani, Hikaru| Araki, Hiroyuki| Sudo, Michiyasu| Tanizaki, Yoshiro| Tada, Sinya| Takahashi, Kiyoshi| Kimura, Ikuro| Matsuoka, Hiroyuki| Ishii, Akira|
Abstract 近年ユスリカが気管支喘息の原因抗原となり得ることが報告されている。しかし,その臨床的特徴はいまだ明らかにされていない。このユスリカ抗原の特徴を検討する目的で,気管支喘息症例163例をHD(ハウスダスト)に感作されたRAST score2+以上の陽性例82例とscore1+以下の陰性例81例とに分けて比較検討を行なった。その結果皮膚反応,ヒスタミン遊離,CTT抗原を用いた特異的IgE抗体いずれの検討においても,HDに感作された症例が,よりユスリカ抗原にも感作されやすいことが明らかになった。
Abstract Alternative In recent years it has been reported that chironomid migdes might be one of the causative allergens in bronchial asthma. In order to clarify the clinical characteristics of bronchial asthma induced by chironomid midges (Tokunagayusurika akamusi), 163 patients with bronchial asthma were studied. The subjects were divided into two groups ; cases with negative (0~1 + ) and positive (2 + or more) RAST score to house dust. 1. Skin reaction to midges was positive in 54 cases (33.1%) out of 163 patients with bronchial asthma. Thirty-six cases (43.9%) out of 82 asthmatics with positive RAST score to house dust showed positive skin reaction to midges, but in 81 cases with negative RAST score, only 18 cases (22.2%) showed positive skin reaction. 2. Fourteen cases out of 85 asthmatics showed a significant amount of histamine release (more than 15%). A significant amount of histamine release was observed in 12 cases (23.5%) out of 51 cases with positive RAST score, but in only two cases (5.9%) out of 24 cases with negative RAST score. 3. Specific IgE antibodies to CTT (Chiromonus thummi thummi) was positive in 12 cases (18.2%) out of 66 asthmatics. In 41 asthmatics with positive RAST score to house dust, 12 cases (29.3%) showed positive RAST score to CTT, though in 25 cases with negative RAST score to house dust no cases showed positive RAST score to CTT. In conclusion, cases with house dust allergy were more easily sensitized by chironomid migdes than those cases without house dust allergy.
Keywords 気管支喘息 (Bronchial asthma) ユスリカ (Chironomid midges) ヒスタミン遊離 (Histamine release) ハウスダスト (House dust)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 54
End Page 60
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309057
Author Matsubara, Fumie| Sudo, Michiyasu| Tanizaki, Yoshiro|
Published Date 1988-08
Publication Title 環境病態研報告
Volume volume59
Content Type Data or Dataset
JaLCDOI 10.18926/19764
Title Alternative Clinical studies on steroid-dependent intractable asthma
FullText URL 059_047_053.pdf
Author Kitani, Hikaru| Araki, Hiroyuki| Sudo, Michiyasu| Tanizaki, Yoshiro| Tsuji, Mituaki| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract ステロイド依存性重症難治性喘息56例について免疫アレルギー学的検討を行った。その結果41才以降発症のLate Onset Asthmaが約半数を占め,血清IgE値が比較的低値であり,ハウスダストに対しての皮内反応,特異的IgE抗体価,ヒスタミン遊離はいずれも全般的に低く,カンジダに対しての皮内反応,特異的IgG抗体価はむしろ比較的高く,肺機能では末梢気道閉塞の傾向が窺われ,臨床分類では,気管支攣縮+過分泌型,および細気管支閉塞型が多数を占める等の特徴を有することが明らかにされた。
Abstract Alternative Clinical studies on steroid-dependent intractable asthma were carried out in 56 patients relating to immuno-allergic aspects. 1. In most half of the patients with steroid-dependent intractable asthma, age at onset of the disease was 41 years old or over (so-called "Late Onset Asthma"). 2. The frequency of positive skin reaction for house dust was relatively low. whereas that for Candida was relatively high. 3. The serum IgE concentrations of these patients were in general low. Many patients showed low serum IgE concentrations of less than 300IU/ml. The concentrations of specific IgE antibodies for house dust and Candida albicans were also low. 4. The concentrations of specific IgG antibodies for Candida albicans were high compared to those for house dust. 5. Basophil histamine release induced by house dust and Candida albicans was not so remarkable in majoriy of these patients, while anti-IgE-induced histamine release from basophils ranged widely. 6. In these patients, small airway obstruction was suggested in ventilatory function test. 7. In clinical classificatin of asthma, type Ⅰa; bronchospasm type was a few, while type Ⅰb; hypersecretion and type Ⅱ; bronchiolor obstruction type were dominant in the cases studied here.
Keywords ステロイド依存性喘息 (Steroid-dependent asthma) 血清IgE (Serum-IgE) 特異的IgE (Specific lgE) 特異的IgG (Specific IgG) 中高年発症型喘息 (Late onset asthma)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 47
End Page 53
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309074
JaLCDOI 10.18926/19762
Title Alternative Atopic asthma in patients of middle or advanced age
FullText URL 059_042_046.pdf
Author Araki, Hiroyuki| Kitani, Hikaru| Sudo, Michiyasu| Tanizaki, Yoshiro|
Abstract 中高年令(41才以上)のアトピー型喘息患者の特徴を明らかにするために,アトピー型喘息患者88例を0~20才,21~40才,41~60才,61才以上の各年令別に分け,年令,性別,発症年令,既往歴,家族歴,末梢血好酸球,血清IgE値,皮内反応の各項目について検討を加えた。結果は,中高年のアトピー型喘息患者は1)その年代の全喘息患者に占める割合は低く,2)男性が多く,3)平均発症年令は高く,4)その他のアレルギー性疾患の既往歴を持たない症例が比較的多く,5)皮内反応では,ハウスダスト陽性率が比較的低く,カンジダ,アスペルギルスの陽性率は比較的高い傾向にあった。6)家族歴,末梢血好酸球,血清IgE値では,明らかな傾向は認められなかった。
Abstract Alternative In order to elucidate the characteristics of atopic asthma in patients of middle or advanced age (over 41 years old), 88 atopic asthmatic patients were divided into 4 groups according to their ages, 0~20, 21~40, 41~60 and over 61 years old, and age, sex, age of onset, past history, family history, number of peripheral eosinophils, serum IgE and skin test were compared among these groups. The results were as follows: Atopic ashmatic patients of middle or advanced age were 1) less frequent in all asthmatic patients of same age group, 2) more frequent in males than in females, 3) higher in averaged age of onset, 4) more frequent in cases without other allergic past histories, 5) less frequently positive to house dust and more frequently positive to Candida and Aspergillus in skin test, 6) not different in family history, number of peripheral eosinophils and serum IgE compared to other groups.
Keywords アトピー (Atopy) 中高年令者 (patients of middle or advanced age) 喘息 (asthma)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 42
End Page 46
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309184
JaLCDOI 10.18926/19758
Title Alternative Separation of paripheral leukocytes by counterflow centrifugation elutriation
FullText URL 059_037_041.pdf
Author Sudo, Michiyasu| Matsubara, Fumie| Araki, Hiroyuki| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract JE-6B rotor(Beckman)を用いてcounterflow centrifugation elutriationによる末梢血白血球の分離を試み,若干の検討を加えた。1.flow rateが低い場合はリンパ球が大部分を占めたが,flow rateの増加とともに頻度は減少した。2. flow rateの増加とともに,好塩基球の頻度が増加し,9-10ml/minでは頻度のみでなく細胞数の増加も認められた。各fractionにおけるヒスタミン含有量も同様の傾向が認められた。3.好中球のpeakはflow rate 13ml/minであり以後減少を示した。4.最終段階で好酸球が増加傾向を示しChamber内で最も高値を示した。以上の結果よりcounterflow centrifugation elutriationによる末梢血白血球細胞分離は,in vitroにおける実験に有用な手段である可能性が示唆された。
Abstract Alternative Separation of peripheral leukocytes was carried out in 5 healthy subjects by counterflow centrifugation elutriation with JE-6B rotor. 1. Number of lymphocytes was predominant at low flow rate (4.5ml/min) of counterflow centrifugation elutriation. 2. As flow rate was increased (9-10ml/min), the purity and number of basophils, and histamine content in the fraction were gradually increased. 3. The purity and number of neutrophils were gradually increased, and the purity was reached the peak at 13ml/min. 4. The purity and number of eosinophils were gradually increased at the late stage of the centrifugation elutriation. The results obtained here might suggest that cell separation by counterflow centrifugation elutriation is more useful for experiments, especially allergy testing, in vitro.
Keywords 逆流負荷遠心法 (Counterflow centrifugation elutriation) JE-6Bローター (JE-6B rotor) 細胞分離 (Cell separation) 好塩基球 (Basophils)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 37
End Page 41
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309189
Author Sudo, Michiyasu|
Published Date 1987-10-31
Publication Title 岡山医学会雑誌
Volume volume99
Issue issue9-10
Content Type Journal Article
Author Sudo, Michiyasu|
Published Date 1987-10-31
Publication Title 岡山医学会雑誌
Volume volume99
Issue issue9-10
Content Type Journal Article
JaLCDOI 10.18926/11823
Title Alternative Clinical aspects of chronic obstructive lungdisease with small airways obstruction. -Comparison between bronchial asthma and chronic obstructive bronchiol itis-
FullText URL 061_023_029.pdf
Author Sudo, Michiyasu| Mifune, Takashi| Kawauchi, Kazuhisa| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract 細気管支に病変を有すると考えられる気管支喘息(細気管支閉塞型(II型)のアトピー型)と慢性閉塞性細気管支炎の違いについて臨床的に検討を加えた。(1)年令ではやや慢性閉塞性細気管支炎でやや低年令,発症年令では気管支喘息でやや低年令を示したが有意な差はみられなかった。(2)アレルギー学的検討では気管支喘息は明らかに1型アレルギー反応の関与が推測されたが,一方慢性閉塞性細気管支炎では1型アレルギー反応の関与はほとんどみられなかった。(3)Bronchoaiveolar lavage fluid(BALF)中出現細胞の検討では慢性閉塞性細気管支炎において気管支喘息に比べ好中球の有意の増加が観察され,出現率が55%以上の症例ではほぼ全例が慢性閉塞性細気管支炎であった。(4)換気機能による検討では%肺活量,1秒率では差は認められなかったが,気管支喘息で%V50,%V25のような細気管支の閉塞を示すパラメーターの低下傾向がやや高度であった。(5)胸部X線では気管支喘息では,X線上明らかなび四三陰影は認められず,一方慢性閉塞性細気管支炎では過膨脹所見も,び漫性情粒状陰影ともみられる症例が多く認められた。
Abstract Alternative Subjects with bronchial asthma with bronchiolar obstruction (type II) and cases with chronic obstructive bronchiolitis (COB) were compared by clinical characteristics and ezaminations. (1) The mean age was slightly younger in cases with COB than in asthma cases. The mean age at onset was slightly younger in asthma cases than in cases with COB. (2) The cases with asthma showed positive immediate allergic reactions. However the cases with COB didnot show any positive reactions. (3) The frequency of neutro phils in BALF was significantly higher in the cases with COB than in the cases with asthma. The majority of cases with COB showed the high frequency of neutrophils more than 55% in BALF. (4) In the ventilatory function tests the values of % FVC and FEV(1.0%) were not different between the cases with asthma and the cases with COB. The values of % V(50) and % V(25) which represent small airway obstruction were slightly more decreased in cases with asthma than in the cases with COB. (5) Any abnormalities in roentgenograms of the cases with asthma were not distinctly observed, while the cases with COB showed overinflation and diffuse small round opacities.
Keywords 細気管支 (Bronchiole) 気管支喘息 (Bronchial asthma) 細気管支閉塞型 (Bronchiolar obstruction type) 慢性閉塞性細気管支炎 (Chronic obstructive bronchiolitis)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 23
End Page 29
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313789
JaLCDOI 10.18926/11691
Title Alternative Clinical significance of eosinophilic leucocytes in onset mechanisms of bronchial asthma
FullText URL 061_089_097.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 末梢血好酸球が気管支喘息の発症病態にどのように関与しているかについて,1.末梢血好酸球の変動,2.好酸球の局所出現,3,好酸球とアレルギー反応,4.アレルギー反応と好酸球の機能,5.好酸球と喘息の臨床病態の各項目で検討した。その結果,気管支喘息では,全般的に末梢血好酸球増多がみられ,同時にアレルギー反応局所への遊走が観察されること,末梢気 道では,ある程度肺胞マクロファージの出現と逆相関にあること,リンパ球との関連もある程度認められることなどが示された。そして,局所出現した好酸球は,IgE抗体の関与の程度により,その機能が異なる可能性が示唆された。また臨床病型別の検討では,アトピー型ではいずれの臨床山型においても好酸球の出現率は明かな増加傾向を示したが,非アトピー型では,Ib.気管支攣縮+過分二型においてのみ好酸球増多が著明であった。
Abstract Alternative Participation of eosinophil leucocytes in onset mechanisms of bronchial asthma was discussed in following sections ; 1. changes in number of eosinophils in the peripheral blood, 2. emergence of eosinophils in local allergic reaction sites, 3. eosinophils and allergic reactions, 4. different functions of eosinophils III allergic reactions, 5. eosinophils and clinical types of bronchial asthma. The results showed that eosinophilia in the peripheral blood was generally observed in patients with bronchial asthma. In these cases, eosinophils migrated into local allergic reaction sites. A reversed correlation was present between number of eosinophils and macrophages, and number of eosinophils correlated to a certain extent with number of lymphocytes in the small airways and alveolar region. Function of eosinophils was shown to be different between IgE-and non-IgE-mediated reactions, by measurement of arylsulfatase activity III BALF. Marked eosinophilia in BALF was observed in any clinical types of atopic asthma, although eosinophils were increased only in bronchoconstriction + hypersecretion type (type II) of non-atopic asthma.
Keywords 好酸球 (Eosinophils) 肺生検 (Lung biopsy) 気管支肺胞洗浄 (Bronchoalveolar lavage) 臨床病型 (Clinical type) 気管支喘息 (Bronchial asthma)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 89
End Page 97
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313427
Author Matsubara, Fumie| Endou, Hiroi| Sudo, Michiyasu| Tanizaki, Yoshiro|
Published Date 1990-09
Publication Title 環境病態研報告
Volume volume61
Content Type Data or Dataset
JaLCDOI 10.18926/11670
Title Alternative A case of atopic asthma characterized by marked neutrophilia in BALF
FullText URL 061_129_133.pdf
Author Kawauchi, Kazuhisa| Mifune, Takashi| Kitani, Hikaru| Sudo, Michiyasu| Tanizaki, Yoshirou| Kataoka, Hisakazu| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 気管支肺胞洗浄液(BALF)中に高度の好中球の増多が見られ,治療により臨床症状の軽快と共にBALF中の好中球の減少を認めたアトピー型喘息の一例を経験した。経過中5回施行したBALF中の好中球百分率はそれぞれ65.4%,56.2%,42.4%,5.6%,5.6%であり,4回目,5回目では著明な好中球減少を認めた。本症例の如き症例は今後増加することが予想され,その発症病態を含め今後さらに症例を重ねて検討して行く必要があると 考えられた。
Abstract Alternative The clinical course and characteristics of a case with atopic asthma, showing marked neutrophilia in BALF and severe asthma attacks, were observed the frequency of neutrophils in BALF decreased followed by the improvement of her asthma attacks with therapy. The frequency of neutrophils in BALF was 65.4% at the initial stage before the therapy and decreased to 5.6% at attackfree stage after the therapy. The changes in frequency of neutrophils in BALF, obserbed in this case, should be noticed, because the cell in BALF were hardly affected by any treatment.
Keywords アトピー型喘息 (Atopic asthma) 好中球 (Neutrophil) 気管支肺胞洗浄法 (Bronchoaiveolar lavage)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 129
End Page 133
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313690
JaLCDOI 10.18926/11625
Title Alternative Spa therapy for chronic respiratory diseases - in subjects admitted in 1989. -
FullText URL 061_007_015.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 1989年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者85例(延べ90例)を対象に,その背景因子,臨床的特徴,および温泉療法の臨床効果について検討を加えた。(1)対象85例のうちわけは,気管支喘息65例,肺気腫4例,肺結核症4例,アレルギー性肉芽腫性血管炎3例,閉塞性細気管支炎3例,気管支拡張症2例,慢性気管支炎2例,過敏性肺臓炎2例であり,昨年度と異なり肺結核がやや多かったことが特徴的であった。(2)これら85症例のうち,温泉療法を受けた症例は63例(74.1%)であった。(3)温泉療 法を受けた症例の地域分布では,鳥取県からの入院症例51例では32例(62.7%)であり,同様に岡山県からの入院症例20例では19例(95.0%),その他の県からの入院症例14例で12例(85.7%)であった。4.温泉療法の臨床効果は,気管支喘息では51例中著効14例,有効27例,やや有効8例,無効2例であり,明らかな有効例は41例(80.3%)であった。
Abstract Alternative Backgrounds and immunological characteristics were studied in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1989. At the same time, clinical effects of spa therapy were evaluated for these patients. 1. Eighty five patients with chronic respratory diseases comprised 65 patients with bronchial asthma, 4 with pulmonary emphysema, 4 with lung tuberculosis, 3 with allergic granulomatous angitis, 3 with obstructive bronchiolitis, 2 with bronchiectasia, 2 with chronic bronchitis and 2 with hypersensitivity pneumonitis. 2. Sixty three patients (74.1%) out of the 85 cases had spa therapy. 3. Out of 51 patients coming from Tottori prefecture, 32 cases (62.7%) received spa therapy. On the other hand, spa therapy was carried out for 19 cases (95.0%) out of the 20 cases from Okayama prefecture, and for 12 cases (85.7%) out of the 14 cases from the other prefectures (long distant areas). 4. Many cases with bronchial asthma showed low serum levels of IgE (lower than 200 IU/ml), and frequency of positive skin reactions to various allergens was low in the patients with bronchial asthma. Serum cortisol levels were very low in patients with steroid-dependent asthma. 5. Spa therapy was effective in 41 cases (80.3%) out of the 51 patients with bronchial asthma. Spa therapy also effective for patients with obstructive bronchiolitis, and allergic granulomatous angitis.
Keywords 気管支喘息 (Bronchial asthma) 閉塞性細気管支炎 (Obstructive bronchiolitis) 慢性気管支炎 (Chronic bronchitis) 血清コーチゾール値 (Serum cortisol level) 温泉療法 (Spa therapy)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 7
End Page 15
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313875
JaLCDOI 10.18926/11579
Title Alternative 気管支喘息患者末梢血好塩基球の抗ヒトIgEおよびカルシウムイオノフォァA23187に対する反応性について
FullText URL 061_016_022.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Okuda, Hiroyuki| Komagoe, Haruki| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract The release of histamine from basophils induced by anti-lgE and calcium ionophore A 23187 ( Cal) was examined in 27 patients with bronchial asthma and 7 healthy subjects, using a whole blood method. (1)The release of histamine induced by anti-IgE and CaI was significantly higher in atopic asthmatics than in non-atopic cases. (2) The histamine release with anti-lgE and CaI was significantly lower in cases with long-term steroid therapy compared to the release in cases without steroid therapy. (3) The release with anti-lgE and CaI was increased in cases with age of 0-39 years and in cases wpth age at onset of 0-39 years. (4) Anti-IgE induced release correlated to a certain extent with the release induced by CaI. These results show that basophil reactivity as expressed by histamine release changes under different conditions.
Abstract Alternative 気管支喘息27例および健康人7名を対象に,抗ヒトIgEおよびカルシウムイオノフォァA23187(CaI)刺激時の末梢血好塩基球からのヒスタミン遊離について検討を加えた。(1)抗ヒトIgEおよびCaI刺激時の好塩基球からのヒスタミン遊離は,非アトピー型喘息に比べ,アトピー型喘息において有意に高い値を示した。(2)これらの刺激物質によるヒスタミン遊離は,非使用例に比べ,ステロイド依存性喘息において低い傾向がみられた。また,年齢では39才以下,発症年齢では39才以下でヒズタミン遊離がより高い傾向がみられた。(3)血清IgE値の高い症例の好塩基球は,低い症例に比べより多くのヒスタミンを遊離する傾向がみられた。(4)全般的には,抗ヒトIgE刺激によるヒスタミン遊離とCaI刺激時の遊離との間にはある程度の相関がみられた。以上の結果より,好塩基球の反応性はいろいろの条件下でかなり異なることが示唆された。
Keywords Histamine release (ヒスタミン遊離) Basophils (好塩基球) Anti-lgE (抗ヒトIgE) Calcium ionophore A 23187 (カルシウムイオノフォァA23187) Bronchial asthma (気管支喘息)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 16
End Page 22
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002313673
JaLCDOI 10.18926/792
Title Alternative In Vitro Rooting and Multiple Buds Formation from Asparagus Lateral Buds with Ancymidol
FullText URL 061_030_035.pdf
Author Mifune, Takashi| Kawauchi, Kazuhisa| Kitani, Hikaru| Sudo, Michiyasu| Tanizaki, Yoshiro|
Abstract 高齢者の増加やいわゆるcompromised hostの増加により,肺結核症の臨床像が変化してきている。肺結核に典型的な臨床像を呈さず,頻回の喀疾検査にても抗酸菌を証明できなかった6症例に対し,気管支肺胞洗浄(bronchoalveolar lavage:BAL)を施行し,得られた洗浄液・吸引液の塗抹標本から抗酸菌を証明し,気管支粘膜の変化を認めた。以上の結果より,気管支型の結核症が増加してきている可能性が考えられた。気管支肺胞洗浄は,気管支型の結核症を含め,結核症の診断に有効と考えられた。
Keywords 肺結核 (Pulmonary tuberculosis) 気管支型結核症 (Tuberculosis of mucous membrane) 気管支肺胞洗浄法 (Bronchoalveolar lavage) 抗酸菌 (Acid fast bacilli)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 30
End Page 35
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002304746