JaLCDOI 10.18926/19710
Title Alternative Study on anti-allergic action of Terfenadine
FullText URL 058_005_011.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Kitani, Hikaru|
Abstract 選択的H(1)受容体拮抗薬であるTerfenadineの抗アレルギー作用,特にIgE系反応によるヒスタミン,およびCa ionophore A23187による好中球からのleukotrienes遊離に対する抑制作用を,ヒト末梢血白血球を用いて検討した。1.Terfenadineは,抗ヒトIgE刺激による健康人好塩基球および特異抗原刺激による気管支喘息患者好塩基球からのヒスタミン遊離に対して,全血法でのin vitro添加実験では有意の抑制作用を示さなかった。 2.洗浄白血球法によるin vitro添加実験では,Terfenadineは特異抗原および抗ヒトIgE刺激時の気管支喘息患者好塩基球からのヒスタミン,Ca ionophore A23187刺激時のleukotriene B(4)遊離に対して有意の抑制効果を示した。3.Terfenadineの内服によるin vivoの抑制実験では,IgE系反応による健康人および気管支喘息患者好塩基球からのヒスタミン遊離に対して有意の抑制効果は見られなかったが,特異抗原による皮膚反応に対しては明らかな抑制作用が観察された。以上より,Terfenadineは,組織肥満細胞および組織へと遊走してきた好塩基球に対してはある程度の抑制作用を有しているものと考えられた。
Abstract Alternative Anti-allergic action of terfenadine, one of the H(1) receptor inhibitors, was examined by human basophil histamine release induced by anti-IgE or a specific allergen (house dust), and the release of leukotriens from leucocytes stimulated by Ca ionophore A23187. 1. Terfenadine did not inhibit the release of histamine from basophils of healthy subjects induced by anti-IgE, and also of patients with bronchial asthma induced by house dust when the in vitro examination was performed by a whole blood method. 2. Histamine release from basophils of patients with bronchial asthma was significantly inhibited when washed leucocytes was preincubated with terfenadine in vitro. The release of LT B(4) from leucocytes was also inhibited. 3. In vivo examination of inhibitory action of terfenadine showed no effect on basophil histamine release of healthy subjects by anti-IgE and of asthmatic subjects by house dust, although skin test by house dust in these subjects was inhibited 60 min after administration in vivo. These results show that terfenadine inhibits the release of chemical mediators from tissue mast cells, and basophils migrating into local allergic sites.
Keywords 夕一フェナンジン (Terfenadine) lgE系反応 (IgE-mediated reaction) ヒスタミン (histamine) 好塩基球 (basophils)
Publication Title 環境病態研報告
Published Date 1987-08
Volume volume58
Start Page 5
End Page 11
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309197
JaLCDOI 10.18926/19683
Title Alternative Studies on anti-allergic actions of tranilast (Rizaben®)
FullText URL 057_042_045.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Morinaga, Hiroshi| Ohtani, Jun| Kimura, Ikuro|
Abstract 抗アレルギー剤(脱顆粒抑制剤)の1つであるtranilastの肥満細胞の遊離機序に対する抑制作用について検討を加えた。1.抗原刺激時の肥満細胞の(45)Ca uptakeおよびヒスタミン遊離に対して,tranilastは有意の抑制作用を示したが,comp.48/80刺激時にはtranilastの(45)Ca uptake,ヒスタミン遊離に対する抑制作用はほとんどみられなかった。2.phosphatidylserine添加時には,(45)Ca uptakeに対するtranilastの抑制作用は減弱傾向を示し,この傾向はヒスタミン遊離に対する作用に比べより高度であった。3.抗原および抗ヒトIgEによる好塩基球からのヒスタミン遊離に対して,tranilastは明らかな抑制作用を示さなかった。
Abstract Alternative Tlanilast is clinically used for bronchial asthma as one of the prophylactic agents for asthma attacks. In this study, anti-allergic actions of tranilast were examined in (45)Ca uptake of and histamine release from target cells of IgE after stimulation with antigen, anti-IgE and camp. 48/80. 1. (45)Ca uptake of and histamine release from rat peritoneal mast cells stimulated by antigen were significantly inhibited by preincubation of the cells with tranilast. Inhibition by tranilast of increased (45)Ca uptake of mast cells by addition of phosphatidylserine were less, although inhibition of histamine release was not so affected by addition of phosphatidylserine. No significant inhibition by tranilast of (45)Ca uptake and histamine release was not observed when the cells were stimulated by camp. 48/80. 2. Tranilast showed any inhibitory effects on basophil histamine release induced by antigen and anti-IgE.
Keywords トラニラスト (tranilast) (45)Ca取り込み ((45)Ca uptake) ヒスタミン遊離 (histamine release) 肥満細胞 (mast cell) 好塩基球 (basophils)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 42
End Page 45
ISSN 09133771
language 日本語
File Version publisher
NAID 120002308998
JaLCDOI 10.18926/19678
Title Alternative Spa therapy for bronchial asthma. Annual changes of characteristics of asthmatics admitted during the past four years.
FullText URL 057_037_041.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Komagoe, Haruki| Morinaga, Hiroshi|
Abstract 1982年1月から1985年12月までの4年間に三朝分院内科へ入院し,温泉療法を受けた気管支喘息45例を対象にその年次推移を検討した。1.性別:初期2年間は男性の入院症例が多い状況であったが,後期2年間では男女比はほぼ等しかった。2.年令:年次推移はみられず,その平均年令は50±2才の間にあった。3.地域分布:初期2年間は岡山県からの入院症例が多数をしめたが,後期2年間ではむしろ鳥取県からの入院症例が増加する傾向がみられた。4.入院期間:初期2年間の平均入院期間は6.7カ月,6.5カ月とかなり長くなる傾向がみられたが,後期2年間ではそれぞれ3.0カ月,1.5カ月と明らかな短縮傾向がみられた。5.臨床病型:いずれの年度においても重症化傾向の強いⅠb型,Ⅱ型が多くみられたが,各年度間には差はみられなかった。6.ステロイド剤使用状況:年度の経過とともにその使用量は減少して いく傾向が示された。
Abstract Alternative Annual changes of characteristics, sex, area (Prefecture) of patients' coming from, term of admission, clinical classification of asthma and use of glucocorticoids, were examined in 45 patients with bronchial asthma who were admitted at Misasa Hospital, Okayama University Medical School and received spa therapy during the past four years from 1982 to 1985. In the first two years from 1982 to 1983, more patients with bronchial asthma were admitted from Okayama Prefecture, and the majority of them had severe asthma attacks and were more dependent on steroid-therapy. On the other hand, in the past two years from 1984 to 1985, number of patients with bronchial asthma from Tottori Prefecture increases, and their attacks were less severe and less dependent on steroid-therapy compared to the patients admitted during the first two years. Term of admission became shorter in the past two years than in the first two years. Any differences between the first and the past two years were not shown in sex, patient age and asthma types classified by clinical symptoms.
Keywords 気管支喘息 (Bronchial asthma) 温泉療法 (spa therapy) 臨床病型 (asthma type)
Publication Title 環境病態研報告
Published Date 1986-07
Volume volume57
Start Page 37
End Page 41
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309135
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kobashi, Hidetoshi| Shioda, Yutaro| Matsuka, Yoko| Takeyama, Hiroyasu| Harada, Hiroshi| Tada, Shinya| Kimura, Ikuro|
Published Date 1983-12-30
Publication Title 岡山医学会雑誌
Volume volume95
Issue issue11-12
Content Type Journal Article
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Nakago, Jitsuo| Morinaga, Hiroshi| Ohtani, Jun| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Published Date 1984-04-30
Publication Title 岡山医学会雑誌
Volume volume96
Issue issue3-4
Content Type Journal Article
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Ohtani, Jun| Kitani, Hikaru| Matsuka, Yohko| Kimura, Ikuro| Akagi, Katsumi| Townley Robert G.|
Published Date 1983-06-30
Publication Title 岡山医学会雑誌
Volume volume95
Issue issue5-6
Content Type Journal Article