FullText URL fulltext.pdf
Author Miyake, Hiromasa| Tanabe, Katsuyuki| Tanimura, Satoshi| Nakashima, Yuri| Morioka, Tomoyo| Masuda, Kana| Sugiyama, Hitoshi| Sato, Yasufumi| Wada, Jun|
Keywords acute kidney injury ischemia-reperfusion oxidative stress vasohibin-2 peritubular capillaries
Published Date 2020-06-26
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue12
Publisher MDPI
Start Page 4545
ISSN 1422-0067
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32604722
DOI 10.3390/ijms21124545
Web of Science KeyUT 000549478900001
Related Url isVersionOf https://doi.org/10.3390/ijms21124545
FullText URL fulltext.pdf
Author Sang, Yizhen| Tsuji, Kenji| Inoue-Torii, Akiko| Fukushima, Kazuhiko| Kitamura, Shinji| Wada, Jun|
Keywords semaphorin3A podocyte proteinuria apoptosis c-Jun N-terminal kinase
Published Date 2020-06-08
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue11
Publisher MDPI
Start Page 4099
ISSN 1422-0067
NCID AA12038549
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32521824
DOI 10.3390/ijms21114099
Web of Science KeyUT 000543400300361
Related Url isVersionOf https://doi.org/10.3390/ijms21114099
FullText URL fulltext.pdf
Author Fukushima, Kazuhiko| Kitamura, Shinji| Tsuji, Kenji| Sang, Yizhen| Wada, Jun|
Keywords sodium glucose co-transporter 2 inhibitor mammalian target of rapamycin (mTOR) autophagy obesity multi lamellar body
Published Date 2020-06-05
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue11
Publisher MDPI
Start Page 4054
ISSN 1422-0067
NCID AA12038549
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors
File Version publisher
PubMed ID 32517059
DOI 10.3390/ijms21114054
Web of Science KeyUT 000543400300316
Related Url isVersionOf https://doi.org/10.3390/ijms21114054
FullText URL fulltext.pdf
Author Yamamura, Yuriko| Matsumoto, Yoshinori| Tadokoro, Koh| Ohta, Yasuyuki| Sato, Kota| Yamashita, Toru| Yamamura, Masahiro| Sada, Ken-Ei| Abe, Koji| Wada, Jun|
Keywords Noninvasive pressure support ventilation Statin-associated necrotizing myopathy BIPAP
Published Date 2020-06-03
Publication Title BMC Pulmonary Medicine
Volume volume20
Issue issue1
Publisher BMC
Start Page 156
ISSN 1471-2466
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32493279
DOI 10.1186/s12890-020-01195-7
Web of Science KeyUT 000540247100001
Related Url isVersionOf https://doi.org/10.1186/s12890-020-01195-7
FullText URL fulltext.pdf
Author Katsuyama, Eri| Miyawaki, Yoshia| Sada, Ken-Ei| Asano, Yosuke| Hayashi, Keigo| Yamamura, Yuriko| Hiramatsu-Asano, Sumie| Morishita, Michiko| Ohashi, Keiji| Watanabe, Haruki| Katsuyama, Takayuki| Narazaki, Mariko| Matsumoto, Yoshinori| Wada, Jun|
Keywords Lupus nephritis Active lesions Chronic lesions Urinary protein Serum creatinine
Published Date 2020-06-01
Publication Title BMC Nephrology
Volume volume21
Issue issue1
Publisher BMC
Start Page 208
ISSN 1471-2369
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32487161
DOI 10.1186/s12882-020-01868-9
Web of Science KeyUT 000538054600002
Related Url isVersionOf https://doi.org/10.1186/s12882-020-01868-9
JaLCDOI 10.18926/AMO/59949
FullText URL 74_3_191.pdf
Author Ohashi, Keiji| Sada, Ken-Ei| Asano, Yosuke| Hayashi, Keigo| Yamamura, Yuriko| Asano, Sumie Hiramatsu| Miyawaki, Yoshia| Morishita, Michiko| Katsuyama, Eri| Watanabe, Haruki| Tatebe, Noriko| Narazaki, Mariko| Matsumoto, Yoshinori| Sunahori-Watanabe, Katsue| Kawabata, Tomoko| Yajima, Nobuyuki| Wada, Jun|
Abstract Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity.
Keywords systemic lupus erythematosus chronic damage glucocorticoids, disease activity disease duration
Amo Type Original Article
Published Date 2020-06
Publication Title Acta Medica Okayama
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 198
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577016
FullText URL fulltext.pdf
Author Ogawa-Akiyama, Ayu| Sugiyama, Hitoshi| Kitagawa, Masashi| Tanaka, Keiko| Kano, Yuzuki| Mise, Koki| Otaka, Nozomu| Tanabe, Katsuyuki| Morinaga, Hiroshi| Kinomura, Masaru| Uchida, Haruhito A.| Wada, Jun|
Published Date 2020-01-24
Publication Title PLoS ONE
Volume volume15
Issue issue1
Publisher Public Library of Science
ISSN 1932-6203
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Ogawa-Akiyama et al.
File Version publisher
PubMed ID 31978139
DOI 10.1371/journal.pone.0228337
Web of Science KeyUT 000534599100142
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0228337
FullText URL fulltext.pdf
Author Matsuoka, Natsumi| Tsuji, Kenji| Ichihara, Eiki| Hara, Takayuki| Fukushima, Kazuhiko| Toma, Kishio| Kitamura, Shinji| Inagaki, Kenichi| Sugiyama, Hitoshi| Wada, Jun|
Keywords Pembrolizumab Hypothyroidism Creatinine Cystatin C
Published Date 2020-03-31
Publication Title BMC Nephrology
Volume volume21
Publisher BMC
Start Page 113
ISSN 1471-2369
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32234009
DOI 10.1186/s12882-020-01775-z
Web of Science KeyUT 000522961400004
Related Url isVersionOf https://doi.org/10.1186/s12882-020-01775-z
FullText URL fulltext.pdf
Author Tsuji, Kenji| Kitamura, Shinji| Wada, Jun|
Keywords mesenchymal stem cell extracellular vesicles microRNA immunomodulation renal regeneration acute kidney injury chronic kidney disease
Published Date 2020-01-23
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue3
Publisher MDPI
Start Page 756
ISSN 1422-0067
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 31979395
DOI 10.3390/ijms21030756
Web of Science KeyUT 000522551601025
Related Url isVersionOf https://doi.org/10.3390/ijms21030756
Author Katayama, Akihiro| Tone, Atsuhito| Watanabe, Mayu| Teshigawara, Sanae| Miyamoto, Satoshi| Eguchi, Jun| Nakatsuka, Atsuko| Shikata, Kenichi| Wada, Jun|
Keywords Hypoglycemia Predictive low glucose management (PLGM) Type 1 diabetes mellitus (T1DM) Sensor-augmented pump therapy (SAP)
Note This fulltext will be abailable in Sep., 2020.|
Publication Title Diabetology International
Volume volume11
Publisher Springer
Start Page 97
End Page 104
ISSN 2190-1678
NCID AA12503387
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version Author
PubMed ID 32206479
DOI 10.1007/s13340-019-00408-7
Web of Science KeyUT 000520711100004
Related Url isVersionOf https://doi.org/10.1007/s13340-019-00408-7
JaLCDOI 10.18926/AMO/57953
FullText URL 74_1_53.pdf
Author Kubota, Risa| Araki, Motoo| Wada, Koichiro| Kawamura, Kasumi| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Ariyoshi, Yuichi| Iwata, Takehiro| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Kano, Yuzuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo|
Abstract We investigated the feasibility of robotic renal autotransplantation (RAT) in a porcine model to reduce invasiveness of RAT. Five pigs underwent robotic RAT using the da Vinci® robotic system. A robotic left nephrectomy was performed in all cases. Robotic RAT was performed on the left side in all but one case. Four ports were used. In 3 cases, the kidney was taken out through the GelPort® and irrigated on ice with Ringer’s solution. In 2 cases, a complete intracorporeal robotic RAT was performed. An end-to-side anastomosis was performed between the renal vein and the external iliac vein and between the renal artery and the external iliac artery. Ureteroneocystostomy was also performed in 2 cases. All cases were performed robotically without open conversion. The median (IQR) console time was 3.1 (0.7) h, and the operative time was 3.8 (1.1) h. The estimated blood loss was 30 (0) ml. The warm ischemia time was 4.0 (0.2) min, and the cold ischemia time was 97 (17) min. Intracorporeal transarterial hypothermic renal perfusion was feasible in the 2 complete intracorporeal robotic RAT cases by using a perfusion catheter through a laparoscopic port. Robotic RAT has the potential to be a new minimally invasive substitute for conventional open surgery.
Keywords renal autotransplantation robotic porcine model transplantation
Amo Type Original Article
Published Date 2020-02
Publication Title Acta Medica Okayama
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 53
End Page 58
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099249
FullText URL JCR25_4_45.pdf Fig.pdf
Author Motokura, Yumi| Watanabe, Haruki| Yamamura, Yuriko| Kano, Yuzuki| Matsumoto, Yoshinori| Kawabata, Tomoko| Sada, Ken-ei| Wada, Jun|
Published Date 2019-06
Publication Title Journal of Clinical Rheumatology
Volume volume25
Issue issue4
Publisher Lippincott, Williams & Wilkins
Start Page 45
End Page 47
ISSN 1076-1608
NCID AA11016642
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 29470260
DOI 10.1097/RHU.0000000000000723
Web of Science KeyUT 000470908400007
Related Url isVersionOf https://doi.org/10.1097/RHU.0000000000000723
FullText URL SR9_1_3054.pdf
Author Hiramatsu, Sumie| Watanabe, Katsue S.| Zeggar, Sonia| Asano, Yosuke| Miyawaki, Yoshia| Yamamura, Yuriko| Katsuyama, Eri| Katsuyama, Takayuki| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Kawabata, Tomoko| Sada, Ken-Ei| Wada, Jun|
Published Date 2019-2-28
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 3054
ISSN 2045-2322
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version Publisher
PubMed ID 30816218
DOI 10.1038/s41598-019-38809-y
Web of Science KeyUT 000459891700064
Related Url isVersionOf https://doi.org/10.1038/s41598-019-38809-y
JaLCDOI 10.18926/AMO/56871
FullText URL 73_3_269.pdf
Author Tsuboi, Ichiro| Araki, Motoo| Fujiwara, Hiroyasu| Iguchi, Toshihiro| Hiraki, Takao| Arichi, Naoko| Kawamura, Kasumi| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Kubota, Risa| Nishimura, Shingo| Sako, Tomoko| Takamoto, Atsushi| Wada, Koichiro| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Yanai, Hiroyuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Wada, Jun| Shiina, Hiroaki| Kanazawa, Susumu| Nasu, Yasutomo|
Abstract Nephron-sparing treatment should be offered whenever possible to avoid dialysis in allograph cases. Cryoablation is a new treatment option for treating small-sized renal cell cancer (RCCs). We report a case of RCC arising in a kidney allograft treated by cryoablation. To our knowledge, this is the first case in Asia of RCC in a renal allograft treated using cryoablation. Contrast-enhanced CT-guided percutaneous renal needle biopsy and cryoablation were used to identify the RCC, which could not be identified by other techniques. The postoperative course was uneventful. Contrast-enhanced CT also showed no recurrence or metastases at the 6-month follow-up.
Keywords cryoablation partial nephrectomy renal cell carcinoma renal allograft renal transplantation
Amo Type Case Report
Published Date 2019-06
Publication Title Acta Medica Okayama
Volume volume73
Issue issue3
Publisher Okayama University Medical School
Start Page 269
End Page 272
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31235976
JaLCDOI 10.18926/AMO/54514
FullText URL 70_4_327.pdf
Author Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi|
Abstract A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.
Keywords metformin CD8+ T cells cancer immunology
Amo Type Clinical Study Protocols
Published Date 2016-08
Publication Title Acta Medica Okayama
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 327
End Page 330
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549683
Web of Science KeyUT 000384748600018
JaLCDOI 10.18926/AMO/54507
FullText URL 70_4_295.pdf
Author Araki, Motoo| Wada, Koichiro| Mitsui, Yosuke| Kubota, Risa| Yoshioka, Takashi| Ariyoshi, Yuichi| Kobayashi, Yasuyuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hiroshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Hotta, Katsuyuki| Nasu, Yasutomo|
Abstract Although graft survival following renal transplantation (RTx) has improved, outcomes following highrisk RTx are variable. Preexisting antibodies, including donor-specific antibodies (DSA), play an important role in graft dysfunction and survival. We have designed a study to investigate the safety and efficacy of anti-CD20 monoclonal antibodies (rituximab) in high-risk RTx recipients. Major eligibility criteria include: 1) major and minor ABO blood group mismatch, 2) positive DSA. Thirty-five patients will receive 200 mg/body of rituximab. The primary endpoint is the incidence of B cell depletion. This study will clarify whether rituximab is efficacious in improving graft survival in high-risk RTx recipients.
Keywords end-stage renal disease immunosuppression kidney transplantation
Amo Type Clinical Study Protocols
Published Date 2016-08
Publication Title Acta Medica Okayama
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 295
End Page 297
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549676
Web of Science KeyUT 000384748600011
JaLCDOI 10.18926/AMO/54413
FullText URL 70_3_151.pdf
Author Wada, Jun| Nakatsuka, Atsuko|
Abstract The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion and mitophagy to maintain mitochondrial and cellular functions. In obesity and type 2 diabetes, impaired oxidation, reduced mitochondrial contents, lowered rates of oxidative phosphorylation and excessive reactive oxygen species (ROS) production have been reported. Mitochondrial biogenesis is regulated by various transcription factors such as peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), peroxisome proliferator-activated receptors (PPARs), estrogen-related receptors (ERRs), and nuclear respiratory factors (NRFs). Mitochondrial fusion is promoted by mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1), while fission is governed by the recruitment of dynamin-related protein 1 (DRP1) by adaptor proteins such as mitochondrial fission factor (MFF), mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51), and fission 1 (FIS1). Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARKIN promote DRP1-dependent mitochondrial fission, and the outer mitochondrial adaptor MiD51 is required in DRP1 recruitment and PARKIN-dependent mitophagy. This review describes the molecular mechanism of mitochondrial dynamics, its abnormality in diabetes and obesity, and pharmaceuticals targeting mitochondrial biogenesis, fission, fusion and mitophagy.
Keywords fusion fission oxidative stress mitochondria diabetes
Amo Type Review
Published Date 2016-06
Publication Title Acta Medica Okayama
Volume volume70
Issue issue3
Publisher Okayama University Medical School
Start Page 151
End Page 158
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27339203
Web of Science KeyUT 000379406100001
Author Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi|
Published Date 2014-05-25
Publication Title PLOS ONE
Volume volume9
Issue issue3
Content Type Journal Article
Author Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi|
Published Date 2014-01-22
Publication Title PLOS ONE
Volume volume9
Issue issue1
Content Type Journal Article
Author Nakatsuka, Atsuko| Matsuyama, Makoto| Yamaguchi, Satoshi| Katayama, Akihiro| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Ogawa, Daisuke| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Watanabe, Eijiro| Wada, Jun|
Published Date 2016-02-17
Publication Title Scientific Reports
Volume volume6
Content Type Journal Article