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ID 653
Eprint ID
653
FullText URL
Title Alternative
ラッテの血清の成分およびアミノ酸粗成に対するグルココルチコイドの効果
Author
Wada, Hiroshi
Djagra, Ida Bagus
Abstract
For induction of fat deposit in meat, hypothyroidism is the most important factor. This study was carried out to confirm the effect of glucocorticoid on thyroidal function, using rats. Triamcinolone acetonid, a synthetic compound was used as glucocorticoid. Rats of an experimental group were injected singly subcutaneously with 0.9 mg of the compound and another group of rats served as control. The animals were sacrificed by decapitating at 2 hours and 4 hours following the injection. At the time of decapitating, blood was obtained from the animal respectively. A half portion of the blood serum was used for determination of such blood components as total protein (TP), albumin (Alb), globulin (Gl), blood ureal nitrogen (BUN), glucose(Glu), cholesterol (Chol), calcium (Ca), magnesium (Mg) and phosphorus (P). Another half portion of the serum was subjected to amino acid analysis, using a automatic amino acid analyzer. By injection of the glucocorticoid, concentrations of TP, Alb, and Gl decreased, and concentration of amino acids increased. This is due to gluconeogenesis induced by glucocorticoid. Serum phosphorus was elevated, and ratio of Ca/P decreased and P/Mg increased. These are indicative of lowered thyroidal function. Accordingly, glucocorticoid seemed to have a favourable effect on fattening cattle. Results of amino acid assay were summarized in Table 2. Most of amino acids increased by the injection of the compound, except glutamic acid and taurine. This is due to protein catabolism and gluconeogenesis. Concentration of serum glucose consistently increased. Increase of glycine concentration in serum is indicative of hyperthyroidism. This is, however, due to neoglucogenesis by cortisol. Low concentration of Mg is indicative of hyperthyroidism. Further study for the effect of glucocorticoid would be required, since glucocorticoid is considered to accelerate production of lean meat.
Published Date
1983
Publication Title
岡山大学農学部学術報告
Publication Title Alternative
Scientific Reports of the Faculty of Agriculture Okayama University
Volume
volume61
Issue
issue1
Publisher
岡山大学農学部
Publisher Alternative
Faculty of Agriculture, Okayama University
Start Page
39
End Page
44
ISSN
0474-0254
NCID
AN00033029
Content Type
Departmental Bulletin Paper
language
英語
File Version
publisher
Refereed
False
Eprints Journal Name
srfa