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ID 13984
Eprint ID
13984
FullText URL
Thumnail 106_199.pdf 581 KB
Title Alternative
Studies on the effect of chemotherapy for multiple myeloma with analysis of bone lesion Part 2. Examination of bone status in multiple myeloma
Author
Izumi, Ken
Abstract
Bone status is the most important finding in multiple myeloma. The changes in the bone were examined by various methods such as elcation test, bone x-ray, bone scintigraphy, urine hydroxyproline and quantitative bone mineral by computed tomography (QCT). The elcation test was evaluated in 87 patients with multiple myeloma and 15 with osteopor-osis. The maximum value of hypocalcemia induced by elcatonin was ≧0.25 mmol/L which was considered as an abnormal response compared with the mormal response. The elcationin test is related to the prevailing rate of osteoclastic bone resorption. Myeloma patients with advanced bone disease (multiple lytic lesion, Mixed type) had a higher abnormal response such as hypercalcemia, hyper ALP, hot of the bone status, urine hydroxproline and decrease in the bone mineral then myeloma patients with slight bone disease (diffuse proliferation type). Moreover, the elcation test can indicate whether the durg will be effective in the hyper calcemia. We conclude that the elcation test is important in the evaluation of the bone resorption as a simple test for the prognosis and followed up the skeletal disease in the patients with multiple myeloma.
Keywords
多発性骨髄腫
骨状態
骨塩量
エルカトニン負荷試験
ハイドロキシプロリン
Note
原著
Published Date
1994
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
199
End Page
209
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/3-4/106_3-4_199/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
References
1) Sezaki T Izumi K : Tumor distribution classification system for multiple myeloma : Chinical features and prognosis. Acta Haematol Jpn (1986) 49, 1784-1791.
2) Genant HK : Quantitative computed tomography in the assessment of osteoporosis ; im Osteoporosis Update 1987, Genant HK ed. University of California Press. San Frencisco (1987) pp 49-71.
3) Steiger P : Spinal bone mineral density meaured with quantitative, C. T. : effect of region of interst, vertebral level and technique. Radiology (1990) 175, 537-543.
4) 鈴木 聡 : OCT法. 臨放 (1990) 35, 49-56.
5) 和泉 健, 瀬崎達雄 : Bone statusの変化とエルカトニンテストの関係. 骨転移 (1985) 5, 127-130.
6) Bataille R, Legendre C and Sany J : Acute effects of salmon calitonin in multiple myeloma : A valuable method for serial evaluation of osteoblastic lesions and disease activity-A prospective study of 125 patients J Clin Oncol (1985) 3, 220-236.
7) Brucher H : Myelomprobleme. D Tsch Med Wochenschr (1966) 37, 1629-1634.
8) 江口正雄 : 骨粗鬆症と鑑別を要する疾患の臨床検査所見と画像診断. Orthopedics (1990) 26, 13-21.
9) 福永仁夫, 森田陸司 : 骨粗鬆症と非侵襲的骨塩定量. 整・災害 (1990) 33, 1245-1251.
10) 横井秋夫 : 骨粗鬆症の臨床(第3報)ーQCT法による腰推骨塩量測定についてー. 医療 (1991) 45, 42-46.
11) Dure BMG and Salmon SE : A clinical staging system for multiple myeloma : Correlation of measured myeloma cell mass with presenting clinical features, response to treatment and survival. Cancer (1975) 36, 842-854.
12) 大塚信昭 : 多発性骨髄腫の骨病変の検出における骨, 骨髄シンチグラフィーの有用性について. 骨転移 (1986) 3, 19-24.
13) Blanc D, Chapuy MC and Meunier P : Evaluation de I'activite osteoclastique par le test d'hypocal-cemie provoquee par la calcitonine de saumon. Nouv Presse Med (1977) 6, 2489-2494.
14) 和泉 健, 瀬崎達雄, 足立富郎 : 骨髄腫におけるエルカトニン試験による骨病変の評価ー第2報ー. 骨転移 (1988) 5, 67-71.
15) Bataille R : Mechanisms of bone destruction in multiple myeloma : The importance of an unbalanced process in determining the severity of lytic bone diease. J Clin Oncol (1989) 7, 1909-1914.
16) 瀬崎達雄 : 多発性骨髄腫. 臨床血液 (1989) 30, 1216-1219.
17) Bonadonna G, Merlino MJ, Myers WPL and Sonenberg M : Urinary hydoroxyproline and calcium metabolism in patients with cancer. N Engl J Med (1966) 275, 298-305.
18) Dull TA and Henneman PH : Urinary hydroxyproline as an index of collagen turnover in bone. N Engl J Med (1963) 268, 132-134.
19) Niell HB, Neely CL and Palmieri GM : The postsbsortive urinary hydroxyproline (Spot-Hypro) in patients with multiple myeloma, Cancer (1981) 48, 783-787.
20) Allison DJ and Walker A : Urinary hydroxyproline : Creatinine ratio of normal humans at various ages. Clin Chim Acta (1966) 14, 729-734.
language
日本語
OAI-PMH Set
岡山大学
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Sort Key
2
Eprints Journal Name
joma