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ID 30866
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Author
Ota, Zensuke
Kumagai, Isao
Shikata, Kenichi Kaken ID researchmap
Makino, Hirofumi
Abstract

Sprague-Dawley rats, 6 with aminonucleoside nephrosis and 6 controls, were intravenously injected with human liver ferritin isolated from post mortem liver, and their 24-h urine samples were examined for human ferritin by immunoradiometric assay. In rats with aminonucleoside nephrosis, the amount of excreted ferritin in urine was forty times greater than in control rats. Much more monomeric ferritin was excreted than that of polymeric ferritin. We are the first to have utilized human liver ferritin as a tracer to measure a minor amount of ferritin by a commercially available kit. Our present study seems to indicate a critical role for glomerular basement membrane as a size barrier.

Keywords
glomerular permeabillity
size barrier
human liver ferritin
immunoradiometricassay
Amo Type
Article
Published Date
1989-12
Publication Title
Acta Medica Okayama
Volume
volume43
Issue
issue6
Publisher
Okayama University Medical School
Start Page
363
End Page
365
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT