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ID 17099
Eprint ID
17099
FullText URL
Thumnail 89_375.pdf 1.87 MB
Title Alternative
Immunological studies of the streptococcal preparation, OK-432, on neoplasm Part I. Studies on the host-mediated action of the streptococcal preparation, OK-432, on neoplasm
Author
Yasuhara, Shozo
Abstract
A study was made on a mode of action of the streptococcal preparation, OK-432, that is rather difficult to elucidate only in terms of its direct effect on tumor cells. Its results are described below: 1) The survival rate of the ICR mice pretreated i.p. with OK-432 was about twice as high as in the nontreated group at 40 days after i.v. inoculation of Ehrlich carcinoma. 2) The survival rate of the C3H mice pretreated i.p. with OK-432 was more prolonged than the rate of nontreated group and post-treated group with OK-432 at 50 days after i.p. inoculation of methylcholanthrene-induced sarcoma. 3) The survival rate of the ICR mice pretreated s.c. with OK-432 was slightly prolonged than the rate of nontreated group at 40 days after i.p. inoculation of Ehrlich carcinoma. 4) The appearance of methylcholanthrene-induced sarcoma of the C3H mice pretreated i.p. with OK-432 was significantly delayed, compared with the nontreated group and the posttreated group at 80 days after injection s.c. with methylcholanthrene. The results stated above lead to the conclusion that OK-432 has a host-mediated antitumor action.
Published Date
1977-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume89
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
375
End Page
383
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/89/3-4/89_3-4_375/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma