このエントリーをはてなブックマークに追加
ID 15957
Eprint ID
15957
FullText URL
Thumnail 100_577.pdf 2.29 MB
Title Alternative
Studies on the role of cell mediated immunity in the pathogenesis of intractable asthma -Evaluation of neutrophil chemotactic activity induced by Candida antigen-
Author
Miyagawa, Hidefumi
Abstract
The role of cellular immunity in the pathogenesis of intractable asthma was studied. Increased IL-2 production in intractable asthma patients as the result of lymphocyte response to Candida antigen was shown in the previous paper. Although the exact role of cellular immunity in the pathogenesis of intractable asthma is still obscure, various activities of lymphokines are suspected of contributing to intractable asthma. While neutrophils are well known to release various chemical mediators, neutrophils in bronchoalveolar lavage fluid (BALF) has been reported to increase in patients with intractable asthma. The accumulation of neutrophils could be important in the pathogenesis of intractable asthma. Therefore, neutrophil chemotactic activity (NCA) derived from mononuclear cell culture with Candida antigen was studied. High NCA was observed in patients with intractable asthma in comparison with patients with non-intractable asthma and normal controls. Intractable asthma patients raceiving prednisolone at a done of over 10mg/day showed less NCA than patients receiving prednisolone at a dose of under 10mg/day. NCA levels in the culture supernatant correlated with IL-2 levels in the same culture supernatant. It seemed likely that NCA is derived at least in part, from the lymphocyte blastogenic response to Candida antigen.
Keywords
intractable asthma
Candida antigen
neutrophil chemotactic activity
Published Date
1988
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume100
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
577
End Page
587
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/100/5-6/100_5-6_577/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma