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ID 15967
Eprint ID
15967
FullText URL
Thumnail 99_863.pdf 786 KB
Title Alternative
Effects of copper, cadmium, zinc and two mixtures of these metals on oxidative phosphorylation, ATPase and electron transport of isolated rat liver mitochondoria.
Author
Miyaji, Yoshiyuki
Abstract
The effects of metals on oxdative phosphorylation, ATPase and electron transport were examined. Cadmium accelerated state 4 respiration and increased latent ATPase activity, indicating that cadmium is an uncoupler of the energy transport reaction. Cadmium did not inhibit site 1, 2 or 3 of the electron transport chain. Copper inhibited state 3 respiration, accelerated state 4 respiration, increased latent ATPase activity and decreased stimulated ATPase activity, indicating that copper is an uncoupler and effects the energy tranport reaction. Copper did not inhibit site 1, 2 or 3 of the electron transport chain. Zinc inhibited state 3 and state 4 respiration, increased latent ATPase activity, decreased stimulated ATPase activity slightly, and inhibited sites 1 and 2 of the electron tranport chain. One pair of the 3 metals had additive effects on state 3 and 4 respiratory activity and on stimulated and latent ATPase activity. A competitive reaction between copper and zinc was observed in the effects on sites 1 and 2 of the electron transport chain.
Keywords
Mitochondria
Cadmium
Copper
Zinc
Oxidative phosphorylation
ATPase
Electron Transport System
Published Date
1987-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
863
End Page
879
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/7-8/99_7-8_863/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma