FullText URL JRNC_313_1_169.pdf
Author Kudo, Ken-ichi| Hanafusa, Tadashi| Ono, Toshiro|
Keywords Monoterpenes Linalool X-ray irradiation Reactive oxygen species SSB
Note The final publication is available at Springer
Published Date 2017-07
Publication Title Journal of Radioanalytical and Nuclear Chemistry
Volume volume313
Issue issue1
Publisher Springer
Start Page 169
End Page 174
ISSN 0236-5731
NCID AA11120189
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
Related Url https://doi.org/10.1007/s10967-017-5268-0
JaLCDOI 10.18926/AMO/55204
FullText URL 71_3_219.pdf
Author Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira|
Abstract  Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
Keywords oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry
Amo Type Original Article
Published Date 2017-06
Publication Title Acta Medica Okayama
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 219
End Page 226
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655941
Author Nishiyama, Yuichi| Hanafusa, Tadashi| Yamashita, Jun| Yamamoto, Yoko| Ono, Toshiro|
Published Date 2015-06-20
Publication Title Journal of Radioanalytical and Nuclear Chemistry
Content Type Journal Article
Author Hanafusa, Tadashi| Mohamed, Ali Eldib Ali| Kitaoka, Kenta| Ohue, Yoshihiro| Nakayama, Eiichi| Ono, Toshiro|
Published Date 2011-02-01
Publication Title Cancer Letters
Volume volume301
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/45267
FullText URL 65_2_91.pdf
Author Nagamatsu, Tomohiro| Sakoda, Akihiro| Kataoka, Takahiro| Ono, Toshiro| Yamaoka, Kiyonori|
Abstract No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.
Keywords tobacco radionuclides smoking intake radiation exposure
Amo Type Original Article
Published Date 2011-04
Publication Title Acta Medica Okayama
Volume volume65
Issue issue2
Publisher Okayama University Medical School
Start Page 91
End Page 95
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21519366
Web of Sience KeyUT 000289818800004
JaLCDOI 10.18926/AMO/31119
FullText URL fulltext.pdf
Author Nishioka, Keiko| Saito, Chisato| Nagano, Toshiaki| Okano, Mitsuhiro| Nakagawa, Fumio| Nishioka, Satoko| Masuda, Yu| Ono, Toshiro|
Abstract <p>To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P &#60; 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.</p>
Keywords mite allergen skin test nasal provoration test allergen rhinitis
Amo Type Article
Published Date 1994-10
Publication Title Acta Medica Okayama
Volume volume48
Issue issue5
Publisher Okayama University Medical School
Start Page 279
End Page 282
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7863799
Web of Sience KeyUT A1994PP23600008
JaLCDOI 10.18926/AMO/31114
FullText URL fulltext.pdf
Author Nishioka, Keiko| Saito, Chisato| Nagano, Toshiaki| Okano, Mitsuhiro| Nakagawa, Fumio| Nishioka, Satoko| Masuda, Yu| Ono, Toshiro|
Abstract <p>To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P &#60; 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.</p>
Keywords mite allergen skin test nasal provoration test allergen rhinitis
Amo Type Article
Published Date 1994-10
Publication Title Acta Medica Okayama
Volume volume48
Issue issue5
Publisher Okayama University Medical School
Start Page 279
End Page 282
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7863799
Web of Sience KeyUT A1994PP23600008
Author Hanafusa, Tadashi| Shinji, Toshiyuki| Shiraha, Hidenori| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Yumoto, Eichiro| Ono, Toshiro| Koide, Norio|
Published Date 2005-01-20
Publication Title BMC Cancer
Volume volume5
Content Type Journal Article
Author Nagamatsu, Tomohiro| Hanamoto, Katsumi| Ono, Toshiro| Yamaoka, Kiyonori|
Published Date 2005-12
Publication Title 環境制御
Volume volume27
Content Type Departmental Bulletin Paper
Author Nagamatsu, Tomohiro| Hanafusa, Tadashi| Kinno, Ikuo| Sakoda, Akihiro| Hanamoto, Katsumi| Yamaoka, Kiyonori| Ono, Toshiro|
Published Date 2008-12
Publication Title 環境制御
Volume volume30
Content Type Journal Article
Author Kubota, Naohiro| Potjanapimon, Chaiwat| Fukuda, Fumio| Fujiia, Yuichiro| Ono, Toshiro| Kurafuji, Yuki| Ogoro, Atsuo| Kunugi, Yukihiro| Kobayashi, Kazushi| Shigehara, Izumi| Yamashita, Hiroyuki| Fujishima, Hiroyuki|
Published Date 2009-02
Publication Title 岡山大学農学部学術報告
Volume volume98
Issue issue1
Content Type Departmental Bulletin Paper
Author 小野 俊朗|
Published Date 2002-09-30
Publication Title 岡山医学会雑誌
Volume volume114
Issue issue2
Content Type Journal Article
Author 小野 俊朗|
Published Date 2005-05-30
Publication Title 岡山医学会雑誌
Volume volume115
Issue issue1
Content Type Journal Article
Author Nakagawa, Kazuhiko| Noguchi, Yuji| Okumura, Hideo| Sato, Shuichiro| Tanaka, Motoyuki| Shimono, Michihide| Ali Eldib, Ali Mohamed| Aoe, Motoi| Ono, Toshiro| Uenaka, Akiko| Ohara, Nobuya| Yoshino, Tadashi| Yamashita, Kazuki| Tsunoda, Tsukasa| Shimizu, Nobuyoshi| Nakayama, Eiichi|
Published Date 2007-09-03
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue2
Content Type Journal Article