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Author Obata, Kyoichi| Okui, Tatsuo| Kishimoto, Koji| Ibaragi, Soichiro| Sasaki, Akira|
Published Date 2020-04-28
Publication Title Case Reports in Medicine
Volume volume2020
Publisher Hindawi
Start Page 4814519
ISSN 1687-9627
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Kyoichi Obata et al.
File Version publisher
PubMed ID 32411253
DOI 10.1155/2020/4814519
Web of Science KeyUT 000534278000001
Related Url isVersionOf https://doi.org/10.1155/2020/4814519
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Author Murase, Yurika| Kishimoto, Koji| Yoshida, Shoko| Kunisada, Yuki| Kadoya, Koichi| Ibaragi, Soichiro| Sasaki, Akira|
Published Date 2020-03-28
Publication Title Journal of Surgical Case Reports
Issue issue3
Publisher Oxford University Press
Start Page rjaa061
ISSN 2042-8812
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020.
File Version publisher
PubMed ID 32257103
DOI 10.1093/jscr/rjaa061
Web of Science KeyUT 000535663800034
Related Url isVersionOf https://doi.org/10.1093/jscr/rjaa061
JaLCDOI 10.18926/AMO/31988
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Author Tate, Genshu| Suzuki, Takao| Kishimoto, Koji| Mitsuya, Toshiyuki|
Abstract <p>Mutations of the c-KIT gene have been reported not only in gastrointestinal stromal tumors and mast cell tumors, but also in testicular germ cell tumors (TGCTs). In the present study we employed polymerase chain reaction and DNA sequencing analysis to characterize the c-KIT gene in a 29-year-old Japanese patient with bilateral testicular seminomas. Direct sequence analyses revealed a single base substitution in exon 17 in one c-KIT allele, resulting in an amino acid substitution of D816H in this mutated allele. This mutation was found in the left, but not in the right, testicular seminoma. This is the first description of a c-KIT gene mutation in a Japanese patient with bilateral TGCT. The mutational analysis of the c-KIT gene seems to provide crucial information for managing TGCT patients not only in Europe but also in Japan.</p>
Keywords testicular germ-cell tumor seminoma c-KIT CD117
Amo Type Article
Published Date 2005-02
Publication Title Acta Medica Okayama
Volume volume59
Issue issue1
Publisher Okayama University Medical School
Start Page 33
End Page 36
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 15902997
Web of Science KeyUT 000227263300005