JaLCDOI 10.18926/19790
Title Alternative Oxygen inhalation therapy for chronic venous ulcer. -An additional treatment modality-
FullText URL 060_031_034.pdf
Author Komoto, Yoshiaki| Tokunou, Teruo| Soda, Mitsuhiro| Hirai, Shunichi| Morisue, Shinnhachi| Suzuka, Ichio| Sunakawa, Mitsuru| Yorozu, Hidenori|
Abstract 長期にわたり反復する静脈性潰瘍は,静脈圧亢進により拡張した毛細管の増加とその周辺に滲出したフィブリンの沈着により,血液からの酸素,及び栄養物の供給が妨げられている。医用質量分析装置による皮下組織ガス分圧の評価で経鼻的に100 % の酸素吸入により潰瘍周辺への酸素供給が認められたので,重篤臨床例に対して静脈圧減圧処置に加えて酸素吸入を併用したところ,潰瘍の治癒傾向は著しく速くなり,補助療法としての意義を認めた。
Abstract Alternative Prolonged venous hypertension leads to increase the number of dilated capillaries and to fibrin deposition around them which may form a barrier to the diffusion of oxygen and other nutrients from the blood to the tissue, so that cell death and ulceration may occur. Following inhalation of 100 % -O(2), increased partial pressure of subcutaneous tissue oxygen (pO(2)) around the ulcer was confirmed by means of medical mass spectrometry, which was found comparable to or higher than the level of ulcer-free area (chest) on room air. Four patients suffering from chroriic ulcers were successfully treated by 100 % -O(2) inhalation, 4-5 ℓ/min, for one hour every day in addition to the simpie measures of reducing venous stasis. Suffice it to say that the inhalation of 100 % -O(2) may be applicative to an additional treatment modality in chronic venous ulceration, though inhalation of 100 % -O(2) for a long period of time may not be recommended.
Keywords 慢性静脈性潰瘍 (Chronic venous ulcer) 組織ガス分圧 (Partial pressure of tissue gases) 医用質量分析装置 (Medical mass spectrometer) 酸素拡散 (Oxygen diffusion) 酸素吸入療法 (Oxygen inhalation therapy)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 31
End Page 34
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309180