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ID 17112
Eprint ID
17112
FullText URL
Thumnail 89_449.pdf 11.7 MB
Title Alternative
The experimental study on the thrombin induced disseminanted intravascular coagulation
Author
Hoshiai, Seiki
Abstract
Disseminated intravascular coagulation (DIC) models were made by intra-aortic infusion of thrombin (50 units/kg. body weight) during 30 minutes in the dogs. Histological study of glomerular fibrin deposition was taken on the specimens which were collected by the renal biopsy. Changes of blood coagulation system and fibrinolytic factors of blood and urine were studied during 120 minutes. These results were summarized as follows: 1. With the light microscope disappearance of all glomerular fibrin deposits were observed 90 minutes after initial infusion. 2. These results suggest that major mechanism of fibrin removal from capillaries was the intravascular fibrinolysis. 3. In addition, as the another mechanism of fibrin removal the transglomerular passage into urinary space was revealed. 4. Urokinase excretion in urine was reduced continuously until the end of experiment. 5. FDP was measured by serial dilution protamine sulfate test for the estimation of fragement X(0) and soluble fibrin monomer complexes.
Published Date
1977-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume89
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
449
End Page
468
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/89/3-4/89_3-4_449/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma