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ID 18761
Eprint ID
18761
FullText URL
Thumnail 70_137.pdf 1.22 MB
Title Alternative
Studies on the Weil-Felix Reaction of Rickettsia tsutsugamushi The Investigatign on the Weil-Felix Reaction on the Basis of the Concept of 50% Agglutination Titer
Author
Kajiki, Ikuo
Abstract
For the diagnosis of rickettsial diseases, though there are agglutination and complement fixation tests with the use of pure rickettsial suspension, the Weil-Felix test is still of high value for its technical simplicity and specificity. Even in the case of Tsutsugamushi disease, Fletcher, Wolf, Felix and Kawamura applied the Weil-Felix reaction with the use of Proteus OXK bacilli, and since then this reaction has been discussed in various ways, but the true antibody titer seems not to be obtained because of the insufficient consideration of the antigen concentration. Especially when the variation in the production of antibody is discussed on the basis of antibody titer, there apt to be misinterpretations. By the Weil-Felix reaction with the use of Proteus OXK dacilli suspension of 50% agglutination titer as the antigen, the author examined the variation of the antibody production in the sera of the test animals inoculated with rickettsiae, in parallel with the case in which the antigen was selected at random in the conventional way. As the result, it was found that when the antigen of 50% agglutination titer was used, no variation was shown in the antibody titer, irrespective of the sites of inoculation, the number of times of inoculation, life or death of rickettsiae, while, in the case of antigen selected at random, variable titers were yielded. From these data, the author believes that the antigen concentration suitable for she Weil-Felix reaction has been found.
Published Date
1958-01-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue1
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
137
End Page
152
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/1/70_1_137/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma