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ID 52788
JaLCDOI
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Thumnail 68_4_219.pdf 1.23 MB
Author
Hinamoto, Norikazu
Saito, Daisuke
Yamasaki, Hiroko
Nasu, Tatsuyo
Watatani, Hiroyuki
Ujike, Haruyo
Kinomura, Masaru
Sonoda, Hikaru
Kanomata, Naoki
Sato, Yasufumi
Abstract
Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r=0.48, p=0.001) or cortex (r=0.64, p<0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r=0.34, p=0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r=0.44, p=0.01) or medulla (r=0.63, p=0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
Keywords
chronic kidney disease
inflammation
Vasohibin-1
VEGF-A
VEGFR-2
Amo Type
Original Article
Published Date
2014-08
Publication Title
Acta Medica Okayama
Volume
volume68
Issue
issue4
Publisher
Okayama University Medical School
Start Page
219
End Page
233
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2014 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52824