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ID 14442
Eprint ID
14442
FullText URL
Thumnail 103_1.pdf 10.3 MB
Title Alternative
Experimental study of central nervous system stimulation on pain relief -Effect of cerebral cortical stimulation on neuronal activity of subnucleus caudalis of spinal trigeminal nucleus in cat-
Author
Masaoka, Tetsuya
Abstract
The effect of electrical stimulation of cerebral cortex on neuronal activity in the subnucleus caudalis of the spinal trigeminal nucleus (STNcd) was examined electrophysiologically in the cat. The nociceptive neuronal firing in the STNcd was suppressed by electrical stimulation of contralateral cerebral cortex (primary motor : Msl or primary somatosensory : Sml cortical area.) The high amplitude spontaneous and continuous neuronal hyperactivity (deafferentation hyperactivity : DH), which was provoked in the left STNcd after complete ablation of left Gasserian ganglion, was conspicuously suppressed by the electrical stimulation of the cerebral cortex (Msl stimulation : 5/36 ; Sml stimulation : 12/36). Almost all neurons (nociceptive and DH neuron), the neuronal activity of which was suppressed by electrical stimulation of cerebral cortex, were located in the dorsal and ventral reticular subnuclei of STNcd. On the other hand, the injection of wheat germ agglutinin labeling horseradish peroxidase into the cerebral cortex (Msl) demonstrated that the efferent fibers passed through the internal capsule (IC) and projected directly to the dorsal and ventral reticular subnuclei of the STNcd of the contralateral side. This study suggested that the neuronal firing in STNcd (nociceptive neuronal firing and DH) was suppressed by stimulation of the inhibitory efferent fibers from the cerebral cortex to STNcd by electrical stimulation of IC and cerebral cortex.
Keywords
intractale pain
deafferentation hyperactivity
deafferented pain
cerebral cortex
internal capsule
Note
原著
Published Date
1991
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume103
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1
End Page
18
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/103/1-2/103_1-2_1/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma