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ID 40697
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Title Alternative
Studies on the treatment for intractable asthma Part 1. Inhibitory effect of Saiboku-to on type IV allergy in intractable asthma
Author
Eda, Ryosuke
Abstract
In an effort to clarify the clinical and pharmacological effects of Saiboku-to in intractable asthmatics, the effect of a 6 month administration of Saiboku-to on the production of antigen-specific lymphokines were studied. The results revealed, first, that a significant decrease in attacks and steroid-sparing effects were obtained after 3 to 4 months administration of Saiboku-to (P<0.05). Second, peripheral blood lymphocyte blastogenesis by Candida was significantly suppressed after 3 months (P<0.05), though it was not by PHA. Moreover interleukin 2 (IL-2) production and neutrophil chemotatic activity (NCA) in peripheral blood mononuclear cells stimulated by Candida were significantly decreased after 3 months (P<0.01), but not by PHA. Third, in vitro production of both IL-2 and NCA by Candida were suppressed in a dose dependent manner and the augmented expression of IL-2 receptors by Candida was decreased by Saiboku-to. These results suggest that the action mechanism of Saiboku-to in intractable asthma seems to be the suppression of type IV allergy. Therefore Saiboku-to therapy might be a useful treatment for intractable asthma due to its relatively less serious side effects as compared with corticosteroids.
Keywords
難治性喘息
柴朴湯
カンジダ抗原
IV型アレルギー反応
Published Date
1990-12
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume102
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1309
End Page
1321
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/102/11-12/102_11-12_1309/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma