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ID 40698
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Title Alternative
Studies on the treatment for intractable asthma Part 2. Evaluation of the pharmacological action of various Kampo Medicines on lymphocyte and neutrophil functions in intractable asthmatics
Author
Eda, Ryosuke
Abstract
The pharmacological action of Sho-saiko-to and Hange-koboku-to, components of Saiboku-to, as well as that of Sho-seiryu-to were compared with that of Saiboku-to and examined in intractable asthmatics with respect to both lymphocyte functions, including interleukin 2 (IL-2) production and IL-2 receptor expression in peripheral blood lymphocytes stimulated by Candida, and on neutrophil functions, including leukotriene C(4) (LTC(4)) and superoxide (O(2)(-)) production by peripheral blood neutrophils. The results revealed, first, that, Sho-saiko-to, Hange-koboku-to, and Sho-seiryu-to did not have significant suppressive effects on IL-2 production and IL-2 receptor expression by Candia, though Saiboku-to caused significant suppression of these same parameters. Second, after 2 or 3 months oral administration to intractable asthmatics Saiboku-to (TJ-96) suppressed LTC(4) production by peripheral blood neutrophils in response to Candida and Ca-ionophore. Third, in vitro, Saiboku-to caused dose-dependent suppression of both LTC(4) and O(2)(-) production by peripheral blood neutrophils. Sho-saiko-to and Sho-seiryu-to also had suppressive effects on both LTC(4) and O(2)(-) production, with Sho-saiko-to causing the strongest suppression among these drugs. These results indicate that Saiboku-to might be useful in the treatment of intractable asthma due to its suppressive effect on type IV allergy caused by lymphocyte activation by Candida. Moreover, its inhibitory effect of LTC(4) and O(2)(-) production by neutrophils prevents prolonged broncho-constriction and irreversible changes in small airways.
Keywords
難治性喘息
柴朴湯
漢方薬
リンパ球
好中球
Published Date
1990-12
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume102
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1323
End Page
1332
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/102/11-12/102_11-12_1323/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma