このエントリーをはてなブックマークに追加
ID 51031
FullText URL
Author
Inoue, Kiyomi
Sakano, Noriko
Sato, Yoshie
Kanbara, Sakiko
Miyatake, Nobuyuki
Abstract
Serum ceruloplasmin (CP), a marker relevant to copper metabolism, is one of famous inflammation markers with a reduction in Wilson's disease, whereas serum ferritin is a marker relevant to iron metabolism. Recently, ferritin is pointed out to be related with oxidative stress. However, there is still no population research which showed the relation of CP and ferritin. Therefore, we investigated the relationship between CP and ferritin including oxidative stress biomarkers among healthy Japanese (n = 389). We measured serum CP, ferritin, Fe, high-sensitivity C-reactive protein (hs-CRP), and urinary oxidative stress biomarkers [H2O2, 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-isoprostane] and so on. Subjects showed that age; 41.7 ± 10.0 (year), CP; 31.9 ± 6.8 (mg/dl), ferritin; 123.5 ± 121.0 (ng/ml), hs-CRP; 0.89 ± 2.53 (mg/l), 8-OHdG; 10.2 ± 4.4 [ng/mg creatinine (Cre)] and H2O2; 6.5 ± 10.9 (µM/g Cre), (All data mentioned above were expressed as mean ± SD). CP was significantly and positively correlated with hs-CRP and inversely correlated with ferritin, Fe and 8-OHdG. By a multiple logistic regression analysis, odds ratio of CP according to quartiles of hs-CRP was 4.86, and according to quartiles of 8-OHdG was 0.39 after adjusting for age and other confounding factors. In conclusion, our findings suggest that CP was an antioxidative biomarker which controls oxidative stress, whereas ferritin was a marker which may participate in the generation of oxidative stress.
Keywords
ceruloplasmin
ferritin
8-OHdG
oxidative stress
high-sensitivity C-reactive protein
Published Date
2013-03-01
Publication Title
Journal of Clinical Biochemistry and Nutrition
Volume
volume52
Issue
issue2
Publisher
The Editorial Secretariat of JCBN
Start Page
160
End Page
166
ISSN
0912-0009
NCID
AA10710201
Content Type
Journal Article
Official Url
http://dx.doi.org/10.3164/jcbn.12-122
language
英語
Copyright Holders
© 2013 JCBN
File Version
publisher
Refereed
True
DOI
PubMed ID