Author Kitani, Hikaru| Mifune, Takashi| Kawauchi, Kazuhisa| Okazaki, Morihiro| Tanizaki, Yoshiro| Takahashi, Hisaho| Tada, Sinya| Takahashi, Kiyoshi| Kimura, Ikuro| Ishii, Akira|
Published Date 1990-10
Publication Title 岡山医学会雑誌
Volume volume102
Issue issue9-10
Content Type Journal Article
JaLCDOI 10.18926/19842
Title Alternative ステロイド依存性重症難治性喘息に対する温泉療法の遠隔効果
FullText URL 061_001_006.pdf
Author Tanazaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Okuda, Hiroyuki| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract The immediate effects (IEs) and distant effects (DEs) of spa therapy were observed in 67 patients with steroid- dependent intractable asthma (SDIA). (1) The IEs of spa therapy evaluated one week after spa therapy were considerably high, and the efficacy rate was 61.5% in type Ⅰa, 82.7% in type Ⅰb, and 83.4% in type Ⅱ asthmatics. (2) The DEs of spa therapy on SDIA were also observed. The efficacy rate was 50.2% in type Ⅰa, 54.3% in type Ⅰb and 63.7% in type Ⅱ asthmatics. (3) The DEs of spa therapy were different between cases with and without maintenance therapy (MT). The efficacy rate of DEs was generally high (72.8~91.7%) in cases with MT, and low (16.7~40.0%) in cases without MT. These results show that MT is very important to keep the IEs of spa therapy high for a long time.
Abstract Alternative 67例のステロイド依存性重症難治性喘息を対象に,温泉療法を行い,その即時的効果(1週間後)および遠隔効果(1年後),さらには,温泉療法後の継続療法の影響などについて検討を加えた。1.温泉療法1週間後の即時的効果は比較的高く,その有効率は,Ⅰa.気管支攣縮型で61.5%,Ⅰb.気管支攣縮+過分泌型で82.7%,Ⅱ.細気管支閉塞型で83.4%であった。2.温泉療法の遠隔効果では,その有効率は,Ⅰa型で50.2%,Ⅰb型で54.1%,Ⅱ型で63.7%であった。3.温泉療法の遠隔効果は,その後の継続療法の有無によりかなり異なった結果であった。すなわち,継続療法を行った症例の有効率は,72.8~91.7%と高く,一方,継続療法を行わなかった症例の有効率は,16.7~40.0%の間にあった。これらの結果から,温泉療法の即時的効果を保つためには,その後の継続療法が極めて重要であることが示唆された。
Keywords lmmediate effects (即時的効果) Distant effects (遠隔効果) Maintenance therapy (継続療法) Spa therapy (温泉療法) Steroid-dependent intractable asthma (ステロイド依存性重症難治性喘息)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 1
End Page 6
ISSN 09133771
language 英語
File Version publisher
NAID 120002309169
Author Kawauchi, Kazuhisa|
Published Date 1994-08
Publication Title 岡山医学会雑誌
Volume volume106
Issue issue7-8
Content Type Journal Article
JaLCDOI 10.18926/11823
Title Alternative Clinical aspects of chronic obstructive lungdisease with small airways obstruction. -Comparison between bronchial asthma and chronic obstructive bronchiol itis-
FullText URL 061_023_029.pdf
Author Sudo, Michiyasu| Mifune, Takashi| Kawauchi, Kazuhisa| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract 細気管支に病変を有すると考えられる気管支喘息(細気管支閉塞型(II型)のアトピー型)と慢性閉塞性細気管支炎の違いについて臨床的に検討を加えた。(1)年令ではやや慢性閉塞性細気管支炎でやや低年令,発症年令では気管支喘息でやや低年令を示したが有意な差はみられなかった。(2)アレルギー学的検討では気管支喘息は明らかに1型アレルギー反応の関与が推測されたが,一方慢性閉塞性細気管支炎では1型アレルギー反応の関与はほとんどみられなかった。(3)Bronchoaiveolar lavage fluid(BALF)中出現細胞の検討では慢性閉塞性細気管支炎において気管支喘息に比べ好中球の有意の増加が観察され,出現率が55%以上の症例ではほぼ全例が慢性閉塞性細気管支炎であった。(4)換気機能による検討では%肺活量,1秒率では差は認められなかったが,気管支喘息で%V50,%V25のような細気管支の閉塞を示すパラメーターの低下傾向がやや高度であった。(5)胸部X線では気管支喘息では,X線上明らかなび四三陰影は認められず,一方慢性閉塞性細気管支炎では過膨脹所見も,び漫性情粒状陰影ともみられる症例が多く認められた。
Abstract Alternative Subjects with bronchial asthma with bronchiolar obstruction (type II) and cases with chronic obstructive bronchiolitis (COB) were compared by clinical characteristics and ezaminations. (1) The mean age was slightly younger in cases with COB than in asthma cases. The mean age at onset was slightly younger in asthma cases than in cases with COB. (2) The cases with asthma showed positive immediate allergic reactions. However the cases with COB didnot show any positive reactions. (3) The frequency of neutro phils in BALF was significantly higher in the cases with COB than in the cases with asthma. The majority of cases with COB showed the high frequency of neutrophils more than 55% in BALF. (4) In the ventilatory function tests the values of % FVC and FEV(1.0%) were not different between the cases with asthma and the cases with COB. The values of % V(50) and % V(25) which represent small airway obstruction were slightly more decreased in cases with asthma than in the cases with COB. (5) Any abnormalities in roentgenograms of the cases with asthma were not distinctly observed, while the cases with COB showed overinflation and diffuse small round opacities.
Keywords 細気管支 (Bronchiole) 気管支喘息 (Bronchial asthma) 細気管支閉塞型 (Bronchiolar obstruction type) 慢性閉塞性細気管支炎 (Chronic obstructive bronchiolitis)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 23
End Page 29
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313789
JaLCDOI 10.18926/11691
Title Alternative Clinical significance of eosinophilic leucocytes in onset mechanisms of bronchial asthma
FullText URL 061_089_097.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 末梢血好酸球が気管支喘息の発症病態にどのように関与しているかについて,1.末梢血好酸球の変動,2.好酸球の局所出現,3,好酸球とアレルギー反応,4.アレルギー反応と好酸球の機能,5.好酸球と喘息の臨床病態の各項目で検討した。その結果,気管支喘息では,全般的に末梢血好酸球増多がみられ,同時にアレルギー反応局所への遊走が観察されること,末梢気 道では,ある程度肺胞マクロファージの出現と逆相関にあること,リンパ球との関連もある程度認められることなどが示された。そして,局所出現した好酸球は,IgE抗体の関与の程度により,その機能が異なる可能性が示唆された。また臨床病型別の検討では,アトピー型ではいずれの臨床山型においても好酸球の出現率は明かな増加傾向を示したが,非アトピー型では,Ib.気管支攣縮+過分二型においてのみ好酸球増多が著明であった。
Abstract Alternative Participation of eosinophil leucocytes in onset mechanisms of bronchial asthma was discussed in following sections ; 1. changes in number of eosinophils in the peripheral blood, 2. emergence of eosinophils in local allergic reaction sites, 3. eosinophils and allergic reactions, 4. different functions of eosinophils III allergic reactions, 5. eosinophils and clinical types of bronchial asthma. The results showed that eosinophilia in the peripheral blood was generally observed in patients with bronchial asthma. In these cases, eosinophils migrated into local allergic reaction sites. A reversed correlation was present between number of eosinophils and macrophages, and number of eosinophils correlated to a certain extent with number of lymphocytes in the small airways and alveolar region. Function of eosinophils was shown to be different between IgE-and non-IgE-mediated reactions, by measurement of arylsulfatase activity III BALF. Marked eosinophilia in BALF was observed in any clinical types of atopic asthma, although eosinophils were increased only in bronchoconstriction + hypersecretion type (type II) of non-atopic asthma.
Keywords 好酸球 (Eosinophils) 肺生検 (Lung biopsy) 気管支肺胞洗浄 (Bronchoalveolar lavage) 臨床病型 (Clinical type) 気管支喘息 (Bronchial asthma)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 89
End Page 97
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313427
JaLCDOI 10.18926/11670
Title Alternative A case of atopic asthma characterized by marked neutrophilia in BALF
FullText URL 061_129_133.pdf
Author Kawauchi, Kazuhisa| Mifune, Takashi| Kitani, Hikaru| Sudo, Michiyasu| Tanizaki, Yoshirou| Kataoka, Hisakazu| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 気管支肺胞洗浄液(BALF)中に高度の好中球の増多が見られ,治療により臨床症状の軽快と共にBALF中の好中球の減少を認めたアトピー型喘息の一例を経験した。経過中5回施行したBALF中の好中球百分率はそれぞれ65.4%,56.2%,42.4%,5.6%,5.6%であり,4回目,5回目では著明な好中球減少を認めた。本症例の如き症例は今後増加することが予想され,その発症病態を含め今後さらに症例を重ねて検討して行く必要があると 考えられた。
Abstract Alternative The clinical course and characteristics of a case with atopic asthma, showing marked neutrophilia in BALF and severe asthma attacks, were observed the frequency of neutrophils in BALF decreased followed by the improvement of her asthma attacks with therapy. The frequency of neutrophils in BALF was 65.4% at the initial stage before the therapy and decreased to 5.6% at attackfree stage after the therapy. The changes in frequency of neutrophils in BALF, obserbed in this case, should be noticed, because the cell in BALF were hardly affected by any treatment.
Keywords アトピー型喘息 (Atopic asthma) 好中球 (Neutrophil) 気管支肺胞洗浄法 (Bronchoaiveolar lavage)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 129
End Page 133
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313690
JaLCDOI 10.18926/11625
Title Alternative Spa therapy for chronic respiratory diseases - in subjects admitted in 1989. -
FullText URL 061_007_015.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 1989年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者85例(延べ90例)を対象に,その背景因子,臨床的特徴,および温泉療法の臨床効果について検討を加えた。(1)対象85例のうちわけは,気管支喘息65例,肺気腫4例,肺結核症4例,アレルギー性肉芽腫性血管炎3例,閉塞性細気管支炎3例,気管支拡張症2例,慢性気管支炎2例,過敏性肺臓炎2例であり,昨年度と異なり肺結核がやや多かったことが特徴的であった。(2)これら85症例のうち,温泉療法を受けた症例は63例(74.1%)であった。(3)温泉療 法を受けた症例の地域分布では,鳥取県からの入院症例51例では32例(62.7%)であり,同様に岡山県からの入院症例20例では19例(95.0%),その他の県からの入院症例14例で12例(85.7%)であった。4.温泉療法の臨床効果は,気管支喘息では51例中著効14例,有効27例,やや有効8例,無効2例であり,明らかな有効例は41例(80.3%)であった。
Abstract Alternative Backgrounds and immunological characteristics were studied in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1989. At the same time, clinical effects of spa therapy were evaluated for these patients. 1. Eighty five patients with chronic respratory diseases comprised 65 patients with bronchial asthma, 4 with pulmonary emphysema, 4 with lung tuberculosis, 3 with allergic granulomatous angitis, 3 with obstructive bronchiolitis, 2 with bronchiectasia, 2 with chronic bronchitis and 2 with hypersensitivity pneumonitis. 2. Sixty three patients (74.1%) out of the 85 cases had spa therapy. 3. Out of 51 patients coming from Tottori prefecture, 32 cases (62.7%) received spa therapy. On the other hand, spa therapy was carried out for 19 cases (95.0%) out of the 20 cases from Okayama prefecture, and for 12 cases (85.7%) out of the 14 cases from the other prefectures (long distant areas). 4. Many cases with bronchial asthma showed low serum levels of IgE (lower than 200 IU/ml), and frequency of positive skin reactions to various allergens was low in the patients with bronchial asthma. Serum cortisol levels were very low in patients with steroid-dependent asthma. 5. Spa therapy was effective in 41 cases (80.3%) out of the 51 patients with bronchial asthma. Spa therapy also effective for patients with obstructive bronchiolitis, and allergic granulomatous angitis.
Keywords 気管支喘息 (Bronchial asthma) 閉塞性細気管支炎 (Obstructive bronchiolitis) 慢性気管支炎 (Chronic bronchitis) 血清コーチゾール値 (Serum cortisol level) 温泉療法 (Spa therapy)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 7
End Page 15
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313875
JaLCDOI 10.18926/11579
Title Alternative 気管支喘息患者末梢血好塩基球の抗ヒトIgEおよびカルシウムイオノフォァA23187に対する反応性について
FullText URL 061_016_022.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Okuda, Hiroyuki| Komagoe, Haruki| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract The release of histamine from basophils induced by anti-lgE and calcium ionophore A 23187 ( Cal) was examined in 27 patients with bronchial asthma and 7 healthy subjects, using a whole blood method. (1)The release of histamine induced by anti-IgE and CaI was significantly higher in atopic asthmatics than in non-atopic cases. (2) The histamine release with anti-lgE and CaI was significantly lower in cases with long-term steroid therapy compared to the release in cases without steroid therapy. (3) The release with anti-lgE and CaI was increased in cases with age of 0-39 years and in cases wpth age at onset of 0-39 years. (4) Anti-IgE induced release correlated to a certain extent with the release induced by CaI. These results show that basophil reactivity as expressed by histamine release changes under different conditions.
Abstract Alternative 気管支喘息27例および健康人7名を対象に,抗ヒトIgEおよびカルシウムイオノフォァA23187(CaI)刺激時の末梢血好塩基球からのヒスタミン遊離について検討を加えた。(1)抗ヒトIgEおよびCaI刺激時の好塩基球からのヒスタミン遊離は,非アトピー型喘息に比べ,アトピー型喘息において有意に高い値を示した。(2)これらの刺激物質によるヒスタミン遊離は,非使用例に比べ,ステロイド依存性喘息において低い傾向がみられた。また,年齢では39才以下,発症年齢では39才以下でヒズタミン遊離がより高い傾向がみられた。(3)血清IgE値の高い症例の好塩基球は,低い症例に比べより多くのヒスタミンを遊離する傾向がみられた。(4)全般的には,抗ヒトIgE刺激によるヒスタミン遊離とCaI刺激時の遊離との間にはある程度の相関がみられた。以上の結果より,好塩基球の反応性はいろいろの条件下でかなり異なることが示唆された。
Keywords Histamine release (ヒスタミン遊離) Basophils (好塩基球) Anti-lgE (抗ヒトIgE) Calcium ionophore A 23187 (カルシウムイオノフォァA23187) Bronchial asthma (気管支喘息)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 16
End Page 22
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002313673
JaLCDOI 10.18926/792
Title Alternative In Vitro Rooting and Multiple Buds Formation from Asparagus Lateral Buds with Ancymidol
FullText URL 061_030_035.pdf
Author Mifune, Takashi| Kawauchi, Kazuhisa| Kitani, Hikaru| Sudo, Michiyasu| Tanizaki, Yoshiro|
Abstract 高齢者の増加やいわゆるcompromised hostの増加により,肺結核症の臨床像が変化してきている。肺結核に典型的な臨床像を呈さず,頻回の喀疾検査にても抗酸菌を証明できなかった6症例に対し,気管支肺胞洗浄(bronchoalveolar lavage:BAL)を施行し,得られた洗浄液・吸引液の塗抹標本から抗酸菌を証明し,気管支粘膜の変化を認めた。以上の結果より,気管支型の結核症が増加してきている可能性が考えられた。気管支肺胞洗浄は,気管支型の結核症を含め,結核症の診断に有効と考えられた。
Keywords 肺結核 (Pulmonary tuberculosis) 気管支型結核症 (Tuberculosis of mucous membrane) 気管支肺胞洗浄法 (Bronchoalveolar lavage) 抗酸菌 (Acid fast bacilli)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 30
End Page 35
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002304746