Author Naniwa, Hiroyuki|
Published Date 1994-06-30
Publication Title
Content Type Thesis or Dissertation
JaLCDOI 10.18926/11679
Title Alternative Clinical evaluation of new formula included oligopetide as a nitrogen source in surgical patients
Author Soda, Mitsuhiro| Yorozu, Hidenori| Morisue, Sinhachi| Hirai, Shunichi| Suzuka, lchio| Komoto, Yoshiaki| Kajitani, Nobuaki| Yoshizane, Ken| Naniwa, Hiroyuki| Teramoto, Shigeru|
Abstract 窒素源としてdi-,tri-peptideを含有した経腸栄養剤を外科患者に使用した。.この新しい経腸栄養剤は卵白を加水分解したもので,70%がoligopeptideであり,アミノ酸も10%含まれる。糖質はデキストリンで,脂肪の含有量は少なく浸透圧はエレメンタルダイエット(ED)より低い。この製剤を安定期および術後に使用した。アルブミン,rapid turnover proteinの回復がみられ,臓器蛋白の合成が得られた。術後例では3メチルヒスチジンの排泄量は減少せず,異化反応は抑制されなかった。投与量の不足が一つの原因と思われる。副作用の下痢はほとんどみられず,栄養改善効果もあり,有用性が認められた。
Abstract Alternative The clinical usefulness of new enteral formula which is contained di-and tri-peptides as a nitrogen source was evaluated in surgical patients. The enteral nutrition was introduced to stable patients who could not take food orally and postoperative ones who were undertaken upper GI surgery. Adverse effects such as diarrhea or abdomonal distension were not observed. V isceral proteins were improved after administration of this regimen and nutritional status was maintained in all patients. However, high urinary excretion of 3methylhistidine continued in great extent during postopertive period and breakdown of skeletal muscle was not prevented by this nutritional therapy. This might be due to insufficient intake of energy and nitrogen. This new product for enteral nutrition would be safe and useful as enteral nutrition.
Keywords 経腸栄養 (Enteral nutrition) エレメンタルダイエット (Elemental diet) オリゴペプチド (Oligopeptide) 外科栄養 (Surgical nutrition)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 61
End Page 67
ISSN 0913-3771
language 日本語
File Version publisher
JaLCDOI 10.18926/11695
Title Alternative Antithrombogenic therapy after heart valve replacement - Effect of anti-platelet drug on aggregation-
FullText URL 061_055_060.pdf
Author Soda, Mitsuhiro| Yorozu, Hidenori| Suzuka, Ichio| Morisue, Shinhachi| Hirai, Shunnichi| Komoto, Yoshiaki| Kajitani, Nobuaki| Yoshizane, Ken| Naniwa, Hiroyuki| Kojo, Masayoshi| Teramoto, Shigeru|
Abstract 人工弁置換患者の血栓塞栓症(TE)は,長期予後の成績を左右する。 TEを減少させるために凝固因子を抑制するwarfarinと抗血小板剤による抗血栓療法が行われている。人工弁置換患者103例を対象に,抗血小板剤であるtrapidil(TP)とdipyridamole(DP)の血小板凝集能に与える効果を検討した。36ヵ月間検討したが,warfarin単独群は血小板凝集能に変化がなく,TP,DP共にADP凝集能を抑制した。しかし有意差の見られたのは全経過ではなく,凝集能抑制は強力かつ持続的ではなかった。またコラーゲン誘導凝集能は変化を認めなかった。TPとDPの抗血小板効果は同等と思われる。期間中の血栓塞栓発生は,warfarin単独群9.5%,TP群4.3%,DP群7.7%であった。臨床的に抗血小板剤の併用は有効と思われるが,血小板凝集抑制には投与量の増量,あるいは他の薬剤の検討が必要であろう。
Abstract Alternative To evaluate the effect of anti-thrombotic thrapy after valve replacement, serial platelet aggregation measurememnts were carried out in 103 patients. Patients were divided into three groups. e. i. warfarin alone (control), warfarin with trapidil (TP) of 300mg/day and dipyridamole (DP) of 300mg/day. The aggregation of platelet of the control group did not change through 36 months. TP group showed a decrease in platelet aggregation at 24 and 30 months from the pretreatment value. The aggregation of 24 month in TP was significantly lower than that of control. There was no difference of platelet aggregation between TP and DP group. The incidence of thromboembolism of control, TP and DP group were 9.5%, 4.3% and 7.7%, respectively. These data suggest that the supression of platelet aggregation .by TP and DP is not adequate to continue for long time and TP has similar anti-thrombotic effect to DP.
Keywords 人工弁置換術 (Heart valve replacement) 血栓塞栓症 (Thromboembolism) 血小板凝集 (Platelet aggregation) 抗血小板剤 (Anti-thrombotic drug)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 55
End Page 60
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313443
Author Naniwa, Hiroyuki|
Published Date 1994
Publication Title 岡山医学会雑誌
Volume volume106
Issue issue3-4
Content Type Journal Article