start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=19730228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment of malignant tumors with fibroblast-inhibiting agents Part T. Effects of chloroquine on agar granulomas kn-title=線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 第1編 クロロキンの寒天肉芽腫に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Effects of intravenous administration of various chloroquine derivatives (chloroquine diphosphate, chloroquine diorotate, chloroquine chondroitin sulfate and chloroquine polygalacturonate) on rat agar granulomas were studied and the following conclusions were obtained. 1) The weight of agar granulomas was reduced with all four chloroquine derivatives in comparison to that of controls. 2) Histologically, the capsule formation and connective tissue element of agar granulomas were poor in rats given chloroquine. 3) The above findings suggest that chloroquine has affinity to fibroblasts and acts to be inhibitory to these cells. en-copyright= kn-copyright= en-aut-name=ShibuyaKoichi en-aut-sei=Shibuya en-aut-mei=Koichi kn-aut-name=渋谷貢一 kn-aut-sei=渋谷 kn-aut-mei=貢一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科 END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=1-2 article-no= start-page=9 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=19730228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment of malignant tumors with fibroblast-inhibiting agents Part U. Effects of chloroquine on tumor-bearing animals (Bashford cancer) kn-title=線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 第2編 クロロキンの担腫瘍動物(Bashford癌)に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Chloroquine diphosphate, as demonstrated to be a fibroblast-inhibiting agent, was employed in an attempt to suppress the growth of cancer indirectly by inhibiting the interstitial connective tissue of cancer. Bashford cancer which is relatively rich in the interstitium was tested with this agent and the following results were obtained. 1) Chloroquine diphosphate clearly retarded the growth of Bashford cancer. The daily intraperitoneal dose of 25mg/kg was more effective than 10mg/kg. 2) The life span of the tumor-bearing animals was slightly prolonged as compared to controls. 3) The above data were supported by the collateral experimental results; an increase of tumor tissue necrosis as shown by histological and histochemical studies, a decrease of connective tissue elements and acid mucopolysaccharide, inhibition of lowering of liver catalase activity, and a decrease of iron in the tumor and other organs. en-copyright= kn-copyright= en-aut-name=ShibuyaKoichi en-aut-sei=Shibuya en-aut-mei=Koichi kn-aut-name=渋谷貢一 kn-aut-sei=渋谷 kn-aut-mei=貢一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科 END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=1-2 article-no= start-page=15 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=19730228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment of malignant tumors with fibroblast-inhibiting agents Part V. Effects of chloroquine on tumor-bearing animals (Ehrlich ascites carcinoma and MH 134 ascites hepatoma) kn-title=線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 第3編 クロロキンの担腫瘍動物（Ehrlich腹水癌, MH134腹水肝癌）に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Effects of fibroblast-inhibiting chloroquine diphosphate on ascites tumors such as Ehrlich ascites carcinoma and MH 134 ascites hepatoma weres tudied and the following results were obtained. 1) The survival of animals with Ehrlich ascites carcinoma was not prolonged but the tumor cells in the ascites tended to show a silght decrase. 2) The subcutaneous nodules of Ehrlich carcinoma and MH 134 hepatoma were not inhibited nor were the life span of tumor-bearing animals prolonged. 3) Implantantation of Ehrlich ascites carcinoma cells in vitro treated with the drug showed no difference from control. en-copyright= kn-copyright= en-aut-name=ShibuyaKoichi en-aut-sei=Shibuya en-aut-mei=Koichi kn-aut-name=渋谷貢一 kn-aut-sei=渋谷 kn-aut-mei=貢一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科 END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=1-2 article-no= start-page=23 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=19730228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment of malignant tumors with fibroblast-inhibiting agents Part W. Effects of chloroquine on human tumors kn-title=線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 第4編 クロロキンの人癌に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=An fibroblast-inhibiting agent, chloroquine was administered to cancer patients and the following results were obtined. 1) Chloroquine diphosphate and chloroquine diorotate was given to 54 patients with histologically proven cancers of these it was effective in 38, non-effective in 15 and unknown in 1. The drug was particularly effective in lung cancer (12/13) and bladder cancer (6/8). In effective cases, there were alleviation of pain and improvement anemia, blood sedimention rate, serum protein and serum iron. Tumor regression often occurred and histologically, tendency of tumor necrosis and inhibition of interstitial connective tissue were observed. 2) The side effects of chloroquine were silght and 8 of 54 patients treated showed slight gastrointestinal, neurological or eye complaints. Hematopoiesis was not impaired. 3) The mechanism of action of this agent seems to be in the inhibition of cancer stromal connective tissue, anti-inflamatory and constiutional humoral effects. 4) Therefore, the indication of this drug includes inoperable cases, pre-and post-operative cases, especially in those who failed to respond to ordinary anti-cancer agents. en-copyright= kn-copyright= en-aut-name=ShibuyaKoichi en-aut-sei=Shibuya en-aut-mei=Koichi kn-aut-name=渋谷貢一 kn-aut-sei=渋谷 kn-aut-mei=貢一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科 END