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ID 17007
Eprint ID
17007
FullText URL
Thumnail 92_267.pdf 237 KB
Title Alternative
Increased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil in reduced glutathione- or vitamin E-treated rats and its unresponsiveness to these drugs in carbon tetrachloride-injured rats
Author
Hobara, Norio
Watanabe, Akiharu
Nagashima, Hideo
Abstract
The pharmacokinetics of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) were analysed by measuring its disappearance rate (K) from the circulating blood using a high-pressure liquid chromatographic technique. An increase in the disappearance rate of FT was observed by treatment with reduced glutathione (GSH)- or tocopheryl nicotinate-treated rats. The clearance rates of FT from the circulating blood in carbon tetrachloride (CCl(4))-injured rats were much smaller than those in untreated rats. The unresponsiveness of K values to treatment with GSH or tocopheryl nicotinate was seen in liver-injured rats.
Keywords
四塩化炭素肝障害
FT
ビタミンE
還元型グルタチオン
血中消失速度定数
Published Date
1980-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume92
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
267
End Page
271
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/92/1-2/92_1-2_267/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma