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ID 17446
Eprint ID
17446
FullText URL
Thumnail 87_611.pdf 186 KB
Title Alternative
Studies on non-bilirubin fraction showing positive diazo-reaction in heterozygote Gunn rat bile
Author
Kondo, Tadasuke
Hirohata, Mamoru
Seo, Kenji
Watanabe, Yutaka
Abstract
Non-bilirubin fraction was extracted from the bile obtained from Wister strain rats and heterozygote Gunn rats, and separated by Ostrow(1)s method with minor modification. Azo-pigments was prepared with the non-bilirubin fraction after addition of Ehrlich(1)s diazo reagent. Significance of non-bilirubin fraction showing positive diazo reaction (NBAPF) was studied on the basis of the relation between the percentage of NBAPF to total bile azo pigments (proportion of NBAPF) and molar ratio of glucuronic acid to the ester-form bilirubin. The following results were obtained; 1) Averaged proportions of NBAPF were 0.94% in Wister strain rats and 2.50% in heterozygote Gunn rats, respectively. The latter proportion was higher than the former but not significant due to the wide variation of the measured values of the latter group. 2) Good correlation between the proportion of NBAPF and the molar ratio of glucuronic acid to the ester-form bilirubin was observed. 3) No significant correlation was observed between the bilirubin concentration in the bile and the molar ratio of glucuronic acid to the ester-form bilirubin or the proportion of NBAPF. 4) These results suggest when the conjugation of bilirubin and glucuronic acid in the liver was impaired, both the excretion of dipyrryl substance yielded from bilirubin and other conjugation mechanism increase compensatory.
Published Date
1975-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume87
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
611
End Page
614
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/87/7-8/87_7-8_611/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma