Author Kataoka, Takahiro|
Published Date 2008-03-25
Publication Title
Content Type Thesis or Dissertation
JaLCDOI 10.18926/15202
Title Alternative Recent trend of research on the nongenotoxic mechanisms of chemical carcinogenesis
FullText URL 014_1_001_014.pdf
Author Yamaoka, Kiyonori| Hanamoto, Katsumi| Ina, Yasuhiro| Kataoka, Takahiro| Kawabe, Atsusi| Sano, Masanobu| Ujifuku, Ayako|
Abstract 本総説は,筆者らが進めている「低線量放射線の健康への影響と医療への応用」に関する研究に資するために調査した,化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向の概要についてまとめたものである。即ち,非遺伝毒性的発がんにおける細胞増殖,シトクロムP450誘導,酸化的ストレス,および遺伝子発現のそれぞれの役割,並びに量的な応答性について言及した。また,後成的発がんにおけるアポトーシス,およびギャップ結合による情報伝達のそれぞれの役割についても触れた。その結果,非遺伝毒性的な発がん物質の作用の様式とメカニズムやこれによる後成的な影響などについては解明さ れつつあり,特に,これらの発がん物質がゲノムDNAに対し直接的な相互作用,突然変異,修飾などを行う発がん物質とは機能的に異なった作用をすることが明らかになった。また,これらは放射線発がんなど低線量放射線の健康への影響などについて研究する上で,重要な知見となっていることもわかった。
Abstract Alternative To elucidate the health effects by low dose radiation, we reviewed the recent trend of research on the epigenetic mechanisms of chemical carcinogenesis. The following view were obtained. It has become apparent that chemical and physical agents that induce cancer may do so through different cellular and molecular mechanisms. Investigators, recognizing the apparent differences in the ways compounds participate in the carcinogenesis process, coined the phrases "genotoxic" and "epigenetic" in describing activities of chemicals and physical agents that induced cancer. The term "nongenotoxic" has to some extent replaced "epigenetic" and thus, classification of chemical carcinogens has been frequently delegated to either the genotoxic or nongenotoxic categories. Moreover, while much work remains in the understanding of the modes and mechanisms of action of nongenotoxic carcinogens and the epigenetic effects of these agents, it is apparent that this category of chemicals are functionally different than those compounds which directly interact, mutate, and modify genomic DNA.
Keywords 化学発がん (chemical carcinogenesis) 非遺伝毒性 (nongenotoxicity) 後成説 (epigenesis) 酸化的ストレス (oxidative stress) ギャップ結合 (gap junction)
Publication Title 岡山大学医学部保健学科紀要
Published Date 2003-12-25
Volume volume14
Issue issue1
Start Page 1
End Page 14
ISSN 1345-0948
language 日本語
File Version publisher
NAID 120002307816
JaLCDOI 10.18926/AMO/45267
FullText URL 65_2_91.pdf
Author Nagamatsu, Tomohiro| Sakoda, Akihiro| Kataoka, Takahiro| Ono, Toshiro| Yamaoka, Kiyonori|
Abstract No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.
Keywords tobacco radionuclides smoking intake radiation exposure
Amo Type Original Article
Published Date 2011-04
Publication Title Acta Medica Okayama
Volume volume65
Issue issue2
Publisher Okayama University Medical School
Start Page 91
End Page 95
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21519366
Web of Science KeyUT 000289818800004
Author Kobashi, Yusuke| Kataoka, Takahiro| Kanzaki, Norie| Ishida, Tsuyoshi| Sakoda, Akihiro| Tanaka, Hiroshi| Ishimori, Yuu| Mitsunobu, Fumihiro| Yamaoka, Kiyonori|
Keywords Radon Thoron Oxidative stress Antioxidative function
Note This fulltext is available in Apr. 2021.|
Published Date 2020-04-22
Publication Title Radiation and Environmental Biophysics
Publisher Springer
ISSN 0301634X
NCID AA00800192
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32322961
DOI 10.1007/s00411-020-00843-0
Web of Science KeyUT 000528077400001
Related Url isVersionOf https://doi.org/10.1007/s00411-020-00843-0
Author Yoshimoto, Masaaki| Kataoka, Takahiro| Toyota, Teruaki| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-02-01
Publication Title Inflammation
Volume volume35
Issue issue1
Content Type Journal Article
Author Kataoka, Takahiro| Nishiyama, Yuichi| Toyota, Teruaki| Yoshimoto, Masaaki| Sakoda, Akihiro| Ishimori, Yuu| Aoyama, Yutaka| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2011-12-01
Publication Title Inflammation
Volume volume34
Issue issue6
Content Type Journal Article
Author Kataoka, Takahiro| Teraoka, Junichi| Sakoda, Akihiro| Nishiyama, Yuichi| Yamato, Keiko| Monden, Mayuko| Ishimori, Yuu| Nomura, Takaharu| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-04-01
Publication Title Inflammation
Volume volume35
Issue issue2
Content Type Journal Article
Author Kataoka, Takahiro| Sakoda, Akihiro| Ishimori, Yuu| Toyota, Teruaki| Nishiyama, Yuichi| Tanaka, Hiroshi| Mitsunobu, Fumihiro| Yamaoka, Kiyonori|
Published Date 2011-11-22
Publication Title Journal of Radiation Research
Volume volume52
Issue issue6
Content Type Journal Article
Author Yamaoka, Kiyonori| Kataoka, Takahiro| Nomura, Takaharu| Taguchi, Takehito| Wang, Da-Hong| Mori, Shuji| Hanamoto, Katsumi| Kira, Shohei|
Published Date 2004-05-07
Publication Title Journal of Radiation Research
Volume volume45
Issue issue1
Content Type Journal Article
Author Yamaoka, Kiyonori| Mitsunobu, Fumihiro| Kojima, Shuji| Shibakura, Misako| Kataoka, Takahiro| Hanamoto, Katsumi| Tanizaki, Yoshiro|
Published Date 2005-04-01
Publication Title Journal of Radiation Research
Volume volume46
Issue issue1
Content Type Journal Article
Author Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2007-11-21
Publication Title Journal of Radiation Research
Volume volume48
Issue issue6
Content Type Journal Article
Author Kataoka, Takahiro| Yamaoka, Kiyonori|
Published Date 2012-02-09
Publication Title ISRN Endocrinology
Volume volume2012
Content Type Journal Article
Author Nakagawa, Shinya| Kataoka, Takahiro| Mizuguchi, Yuko| Yoshimoto, Masaaki| Sakoda, Akihiro| Nomura, Takaharu| Wang, Da-Hong| Kawabe, Atsushi| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2008-07
Publication Title Journal of Clinical Biochemistry and Nutrition
Volume volume43
Issue issue1
Content Type Journal Article
Author Kataoka, Takahiro| Yoshimoto, Masaaki| Nakagawa, Shinya| Mizuguchi, Yuko| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2009-09
Publication Title Journal of Clinical Biochemistry and Nutrition
Volume volume45
Issue issue2
Content Type Journal Article
Author Kataoka, Takahiro| Sakoda, Akihiro| Yoshimoto, Masaaki| Nakagawa, Shinya| Toyota, Teruaki| Nishiyama, Yuichi| Yamato, Keiko| Ishimori, Yuu| Kawabe, Atsushi| Hanamoto, Katsumi| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2011-07
Publication Title Radiation Protection Dosimetry
Volume volume146
Issue issue1-3
Content Type Journal Article
Author Nishiyama, Yuichi| Kataoka, Takahiro| Teraoka, Junichi| Sakoda, Akihiro| Ishimori, Yuu| Yamaoka, Kiyonori|
Published Date 2012-05-29
Publication Title RADIOISOTOPES
Volume volume61
Issue issue5
Content Type Journal Article
Author Nakagawa, Shinya| Kataoka, Takahiro| Sakoda, Akihiro| Ishimori, Yuu| Hanamoto, Katsumi| Yamaoka, Kiyonori|
Published Date 2008-04-25
Publication Title RADIOISOTOPES
Volume volume57
Issue issue4
Content Type Journal Article
Author Kataoka, Takahiro| Tokunaga, Rikizo| Sakoda, Akihiro| Kawabe, Atsushi| Hanamoto, Katsumi| Yamaoka, Kiyonori|
Published Date 2012-01-27
Publication Title RADIOISOTOPES
Volume volume61
Issue issue1
Content Type Journal Article
Author Kataoka, Takahiro| Yamato, Keiko| Nishiyama, Yuichi| Morii, Yuji| Etani, Reo| Takata, Yuji| Hanamoto, Katsumi| Kawabe, Atsuishi| Sakoda, Akihiro| Ishimori, Yuu| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-10
Publication Title Renal Failure
Volume volume34
Issue issue9
Content Type Journal Article
Author Kataoka, Takahiro| Nishiyama, Yuichi| Yamato, Keiko| Teraoka, Junichi| Morii, Yuji| Sakoda, Akihiro| Ishimori, Yuu| Taguchi, Takehito| Yamaoka, Kiyonori|
Published Date 2012-07-31
Publication Title Journal of Radiation Research
Volume volume53
Issue issue6
Content Type Journal Article