Acta Medica Okayama1990Antitumor Effect of Natural Human Tumor Necrosis Factor- α and Natural Human Interferon- α in Combination against Human Cancer Transplanted into Nude MiceENYoshioNaomotoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008X 消化管がんに対する現代の標準的治療 〜外科的治療を中心に〜5561ENYoshioNaomotoTomokiYamatsujiYasuhiroShirakawaMunenoriTakaokaYasuhiroFujiwaraShunsukeTanabeNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007食道扁平上皮癌の発癌過程におけるDNAメチル化の役割113117ENTatsuhiroIshiiJunMurakamiKenjiNotoharaHiromiSasamotoTakeshiKambaraYasuhiroShirakawaYoshioNaomotoMamoruOuchidaKenjiShimizuR. JassJeremyNagahideMatsubaraNoriakiTanakaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006乳癌術前化学療法の効果判定における画像診断 われわれが経験した病理判定と画像診断の不一致症例について119121ENJunjiMatsuokaYokoTabuchiMitsuyaItoRyokoOnoTakakoImadaTakayukiMotokiHiroyosiMatsukawaMasakoOhmoriHiroyukiYanaiYoshioNaomotoNoriakiTanakaPrimary systemic chemotherapy (PSC) in breast cancer prolongs disease-free survival in patients who have obtained pathological complete remission (pCR). In combination with pathological examination, CT and MRI have been used to
evaluate the efficacy of PSC, they generally coincide well with pathological evaluation. We here present two cases showing discrepancies between pathological examination and imaging analysis after PSC in breast cancer. We should
keep such discrepancies in mind to determine the ideal treatment after PSC. An accurate method of evaluating cellular damage by PSC is needed.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006乳管洗浄細胞診が診断に有効であった乳癌の一例123125ENJunjiMatsuokaYokoTabuchiRyokoOnoTakakoImadaTatsuoUmeokaNaokiWatanabeTakayukiMotokiHiroyosiMatsukawaYoshioNaomotoNoriakiTanakaHiroyukiYanaiMasakoOmoriAlthough many modalities have been established to diagnose breast cancers, it is sometimes difficult to reveal nonpalpable cases. Duct lavage cytology was originally established to reveal groups at high risk for breast cancers by detecting metaplastic ductal cells. We report here a case where duct lavage was useful for revealing a small cancer that had been undetected by repeated bloody nipple discharge and cytological examinations. Duct lavage cytology may be of use in cases where nipple discharge of unknown origin persists.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006非触知乳癌におけるVATSマーカーを用いたエコーガイド下マーキングの有用性127129ENJunjiMatsuokaYokoTabuchiMitsuyaItoRyokoOnoTakakoImadaHiroyosiMatsukawaTakayukiMotokiYoshioNaomotoSusumuKanazawaA preoperative tumor guiding system for nonpalpable breast cancer using a VATS guiding needle (Hakko Co., Ltd., Tokyo Japan) was reported. It was easy to introduce the guiding needle into breast cancers smaller than 1cm under
ultrasonographic observation. Neither bleeding nor infection was experienced. Wound management was easy and painless. This guiding system is very useful for locating and managing nonpalpable breast cancers even in outpatient
settings.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811812006早期診断し得た食道癌術後静脈血栓塞栓症の2例4145ENTakashiKanazawaNobuyukiWatababeYoshioNaomotoMasahikoKobayashiYasuhiroShirakawaTomokiYamatsujiNaoyaKobayashiTohsiyoshiFujiwaraNagahideMatsubaraHiromiIwagakiJunjiMatsuokaNoriakiTanakaWe encountered two cases of pulmonary embolism (PE)/venous thrombs (DVT) after surgery for esophageal cancer. The first case was a 58-year-old male. He underwent a subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. His postoperative course was stable; however, 13 days after the operation､ he had an elevated fever and pulmonary thrombi were observed on CT-scan screening. Scintigraphy confirmed the thrombi. An inferior vena cava filter (IVCF) was inserted and anti-coagulation therapy using heparin was started. His fever subsided, and 35 days after the operation, the thrombi disappeared. He was discharged thereafter and is being followed up using warfarin. The second case was a 74-year-old male. He also underwent subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. A central line was inserted via right femoral vein; however, the artery was injured and pressurization to the vessel was needed. His post-operative course was stable and symptom-free; however, ultrasound screening detected DVT in his right femoral vein. IVCF was mserted and anti-coagulation therapy was begun, thrombi disappeared 8 days after the therapy.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-15581077-81995食道粘膜癌に対する内視鏡的食道粘膜切除術155160ENYasuakiKamikawaYoshioNaomotoMinoruHaisaHirokazuUetsukaFumiyukiInoueMadokaHamadaJunMoriAkihisaKanekoTakahitoYagiTakahiroOkabayashiNoriakiTanakaKunzoOritaFrom December 1992 to October 1994, 15 patients who had esophageal superficial mucosal lesions (18 lesions) underwent endoscopic esophageal mucosal resection (EEMR). Among them, 12 cases and 12 lesions were squamous cell carcinomas. Although perforation complicated this procedure in one patient and hemorrhage in another, these were improvde by conservative treatment. Marked subcutaneous emphysema occurred in the neck and face during EEMR without esophageal perforation in one patient. Therfore the procedure was stopped and the patient underwent radical operation 41 days later. Two of the 12 patients with carcinoma underwent radical operation 30 days after EEMR because pathological study revealed m3 and ly1 in one them and sm1, ly2 and v1 in the other. Radiotherapy was indicated for another patient who had m3, ly0 and v0. In the other patients, the cancerous lesions devaloped within m2, ly0 and v0 except in one who had minimal m3 invasion, and the therapy was completed with only EEMR. The mean period of observation after EEMR was 15.1 months (7-24). Follow-up did not reveal any recurrence of carcinoma in these 9 patients. EEMR seems to be a highly useful method for treatment of esophageal mucosal carcinoma.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-15581041-21992ヌードマウス可移植性ヒト大腸癌細胞株 LoVoに対する interferon-α,-γ, tumor necrosis factor-α の抗腫瘍効果の検討2127ENKazuhikoKataokaYoshioNaomotoMasahikoMuroKazushiKojimaSadayukiHorikiAkioHizutaNoriakiTanakaKunzoOritaWe investigated the in vivo antitumor effect of recombinant human interferon-α,γ (IFN-α,γ) and/or recombinant human tumor necrosis factor-α (TNF-α) against human colon cancer cells (LoVo) transplanted into nude mice. LoVo cells were very sensitive to IFN-γ and slightly sensitive to IFN-α and resistant to TNF-α in vitro by dye uptake method. Intravenous administration of IFN-γ significantly inhibited tumor growth transplanted subcutaneously into nude mice, but IFN-α and/or TNF-α did not show any antitumor effect. Labeling index on stanining with bromodeoxyuridune and mitotic index of LoVo cells treated with IFN-α,γ or TNF-α differed slightly from those of the control group. We previously reported that the synergistic antitumor effects on the three cell lines could be examined by the combined use of IFN-α and TNF-α and the mechanism of the synergism was arrested in the S phase of cell cycle of target cells. However in the cese of LoVo cells, the combined use of IFN-α and TNF-α was not effective and did not arrest the cells in tha S phase of cell cycle. Therefore, arrest in the S phase was suspected to be responsible from the synergistic antitumor activity of IFN-α and TNF-α on the sensitive targets.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-15581049-101992肺癌における簡易式一時バイパス法を用いた大動脈合併切除の一例923929ENFumiyukiInoueYasuakiKamikawaYoshioNaomotoAkiraGouchiKunzoOritaTakatoHataMasahikoKuinoseHirofumiNanbaGyouTaniguchiLeft pneumonectomy and concomitant resection of the invaded aorta were performed by the simple temporary bypass method. The patient was a 59-year-old male with the chief complaint of left thoracic pain. The 57×43×35 mm tumor was in a region centering on segment 6 of the left lung and had infiltrated the descending aorta. It was diagnosed as T4NOMO, Stage IIIb. A bypass for blood flow was established between the aortic arch avobe the invasion and the left femoral artery, after ligation of the pulmonary artery and vein and closure of the left bronchial stump. Vascular blocking forceps were applied to the descending aorta above and below the tumor infiltration, and two thirds of the circumference of the invaded aortic wall, 4.0×3.0 cm, along with the tumor, was resected. Reconstruction was performed with an 18mm Cooly double velour graft. Blood pressure was monitored with a pressure probe inserted into the right femoral artery. It did not fall below 60 mmHg during the operation. Local recurrence was observed 10 montns post-operatively, and the patient is now receiving radiation therapy.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812112009中国四国広域プロ養成プログラム ―チーム医療を担うがん専門医療人の育成―www.chushiganpro.jp2933ENJunjiMatsuokaYoshioNaomotoMasahiroTabataYasuhiroShirakawaKatsuyukiHottaMitsuneTanimotoNoriakiTanakaNo potential conflict of interest relevant to this article was reported.岡山大学医学部保健学科Acta Medica Okayama1345-09481512004インピーダンス咽頭図(IPG)を用いた加齢による嚥下機能減退の定量的評価法17ENToshimasaKusuharaTakaoNakamuraKeikoMoriYoshitakeYamamotoYasuhiroShirakawaYoshioNaomotoインピーダンス咽頭図(Impedance Pharyngography, 以下IPG)は嚥下活動中の頸部電気インピーダンスを測定するもので,嚥下機能評価を簡便かつ無侵襲に行うことができる手法である｡IPG波形は嚥下機能を反映するものであるが嚥下機能の減退による波形への影響はその原因により様々である｡すなわち嚥下機能の状態が異なる被験者のIPG波形を直接比較･診断することは測定者の主観に依存することになり客観性に欠ける｡本研究では,まず青年健常者のNormal IPGをもとに嚥下機能が反映される波形の特徴を評価するパラメータとして,咽頭通過時間,インピーダンス変化率,類似度,嚥下音タイミングの4つを採用し,IPCを定量的に評価する手法を提案した｡また,この評価法を高齢者のIPGに適用し,青年健常者に比べて嚥下活動に関与する器官が円滑に活動を履行する能力に減退が生じる様子を定量的に示した｡No potential conflict of interest relevant to this article was reported.岡山大学医学部保健学科Acta Medica Okayama1345-09481322003食道がん患者に対する術前インフォームド･コンセントの検討6775ENKeikoMoriNaomiKanaoKayoNanbaTakakoIshikawaShinyaSaitoYoshioNaomoto食道がん患者が食道切除術を受けることを自己決定する場合には,食道癌であることの告知と､食道癌に対する治療方法に関するインフォームド･コンセントが重要となる｡食道がん患者の治療法選択における自己決定を指向したインフォームド･コンセントの有り様について,質的帰納的に分析した文献は少ない｡今回,食道がん患者に対して,半構成的質問用紙を用いて,面接を実施することで,患者が治療法として手術を自己決定するために役立つインフォームド･コンセントとはどのようにあればいいかを明らかにした｡その結果,患者が食道切除術を受けることを決めるためには,@患者の理解度にあわせ,何度かに分けてインフォームド･コンセントが行われる必要があること,A術後に起こってくる症状,特に患者にとって苦痛を伴う検査,処置等については,患者のパーソナリティーを考えながら,術後のイメージがわくような説明が必要であること,B患者の自己決定に至る過程のみならず,インフォームド･コンセント後においても,患者や家族を支援する体制が重要であること,が明らかになった｡No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812132009特異的プロモータを用いた目的遺伝子発現システムの開発と癌治療への応用157162ENTakuyaFukazawaJunjiMatsuokaTomokiYamatsujiNoriakiTanakaYoshioNaomotoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812212010Focal adhesion kinase (FAK) と Insulin-like growth factor-I receptor (IGF-IR) に対するデュアルチロシンキナーゼ阻害剤の食道腺癌における抗腫瘍効果1725ENNobuyukiWatanabeMunenoriTakaokaKazufumiSakuramaYasukoTomonoShinjiHatakeyamaOsamuOhmoriTakayukiMotokiYasuhiroShirakawaTomokiYamatsujiMinoruHaisaJunjiMatsuokaDavid G.BeerHitoshiNagatsukaNoriakiTanakaYoshioNaomotoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812222010便中メチル化DNA検出による消化器がんスクリーニング：消化器がんを非侵襲的にスクリーニングすることは可能か？107112ENTakeshiNagasakaNoriakiTanakaDong-ShengSunYoshioNaomotoNagahideMastubaraTakahitoYagiToshiyoshiFujiwaraNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155812422012小細胞癌成分を含む食道癌肉腫の１切除例145148ENShunsukeTanabeYasuhiroShirakawaNaoakiMaedaToshiakiOharaKazuhiroNomaKazufumiSakuramaHiroyukiYanaiTomokiYamatsujiYoshioNaomotoToshiyoshiFujiwaraWe experienced a case of esophageal carcinosarcoma with a component of small cell carcinoma. The patient was a 73-year-old man. We administered chemotherapy of CDDP+VP-16, and performed an operation after 2 courses of this chemotherapy. Subtotal esophagectomy and reconstruction with the small intestine was performed. More than three years after resection, he remains alive and recurrence-free. There are few cases of esophageal carcinosarcoma and small cell carcinoma. We report this rare case herein.No potential conflict of interest relevant to this article was reported.