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ID 44086
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Title Alternative
On the mechanismus of the anticoagulant action of heparin
Author
Tamao, Nobutada
Abstract
From my previous report it is supposed that the anticoagulant action of the peanut extract is skin to that of heparin. So I prepared heparin from dog's livers after the method originated by Charles-Scott, and investigated on this action to blood coagulation, comparing with those of the extract of the peanut. The results may be summarized as follows: 1) Heparin did not interfere with the presence of Ca-ion, inhibited the blood coagulation acting as antiprothrombin as well as as antithrombin. 2) The anticoagulant actiom of heparin was markedly inhibited by the addition of fresh serum, but recovered its action to a certain extent 24 hours after the adition, and again diminished gradually with the lapse of time. 3) It may be concluded that the anticoagulant substance contained in the peanut extract is akin to heparin.
Published Date
1942-11-30
Publication Title
岡山医学会雑誌
Volume
volume54
Issue
issue11
Publisher
岡山医学会
Start Page
1917
End Page
1924
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1889/54/11/54_11_1917/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma