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ID 13708
Eprint ID
13708
FullText URL
Thumnail 110_9.pdf 2.82 MB
Title Alternative
Localization of Mn- and Cu/Zn-SOD-like immunoreactive cells in the rat brain
Author
Wang, Yan
Abstract
The localization of manganese (Mn) and copper-zinc (Cu/Zn) superoxide dismutase (SOD)-like immunoreactive (lir) cells in the normal rat brain and the change in numbers of both SOD-lir cortical cells after the injection of ferric chloride into the sensorimotor cortex were investigated immunohistochemically. Large and medium-sized cell bodies, pyramidal to polygonal in shape, were immunostained by anti-Mn-SOD antibody. Most of these were not immunolabeled by anti-GFAP antibody, suggesting that most of the Mn-SOD-lir cells are neurons. These cell bodies were distributed in some selected brain areas with different densities. The densest population of Mn-SOD-lir cells was found in the hypothalamic and limbic structures, and in some brain stem nuclei, such as the thalamic reticular nucleus, the locus ceruleus and the pontine nucleus. Anti-Cu/Zn-SOD antibody immunostained many small round cells throughout both white and gray matter, most of which were also immunolabeled by anti-GFAP antiserum. After intacortical injection of FeCl3, the numbers of Mn- and Cu/Zn-SOD-lir cells per unit area within the adjacent narrow region of the injection site significantly increased 2 and 6 hr after the injection, respectively.
Keywords
Mn-SOD
Cu/Zn-SOD
免疫組織化学
ラット脳内分布
FeCl3 大脳皮質内注入
Note
原著
Published Date
1998-06-25
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume110
Issue
issue1-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
9
End Page
20
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/110/1-6/110_1-6_9/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma