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ID 46942
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Author
Naito, Ichiro
Abstract
Multiplexin (Mp) is the Drosophila orthologue of vertebrate collagens XV and XVIII. Like them, Mp is widely distributed in the basement membranes of the developing embryos, including those of neuroblasts in the central and peripheral nervous systems, visceral muscles of the gut, and contractile cardioblasts. Here we report the identification of mutant larvae bearing piggyBac transposon insertions that exhibit decrease Mp production associated with abdominal cuticular and wing margin defects, malformation of sensory organs and impaired sensitivity to physical stimuli. Additional findings include the abnormal ultrastructure of fatbody associated with abnormal collagen IV deposition, and reduced Wingless deposition. Collectively, these findings are consistent with the notion that Mp is required for the proper formation and/or maintenance of basement membrane, and that Mp may be involved in establishing the Wingless signaling gradients in the Drosophila embryo.
Keywords
Extracellular matrix
Basement membrane
Collagen
Proteoglycan
Chondroitin sulfate
Wingless/Wnt
Published Date
2011-05
Publication Title
Matrix Biology
Volume
volume30
Issue
issue4
Publisher
Elsevier Science BV
Start Page
258
End Page
266
ISSN
0945-053X
NCID
AA10996308
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2011 Elsevier B.V. All rights reserved.
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author
Refereed
True
DOI
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Web of Sience KeyUT