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ID 42753
FullText URL
Thumnail 68_2075.pdf 543 KB
Title Alternative
Relation of the Heinz body in Erythrocyte with Isonicotinic acid Hydrazid and Nitromin
Author
Kanda, M.
Shigenobu, Y.
Miki, H.
Abstract
Experimental studies in both vitro and in vivo on the relation of the Heinz body in erythrocytes with the drug having NH(2)-radical, isonicotinic acid (INAH) and the nitromin (NMO) have been attempted and the results obtained were reported as follows: 1. There seems to be practically no influence on the formation of Heinz body in erythrocytes in vitro of the concentration less than INAH 100mg/dl or NMO 10mg/dl of these drugs used. However, it was found that the formation of Heinz body in erythrocytes could be accelerated in vitro of the drug concentration above INAH 500mg/dl or NMO 50mg/dl. 2. Heinz body in erythrocytes of the circulating blood did not appear when rabbits were administered orally of INAH (4mg/kg pro die) for 17 days; while the Heinz body would show up in the erythrocytes when NMO was intravenously given to rabbits for 30 days, (0.5mg/kg pro die for a period of 18 days and 2mg/kg pro die for remaining 12 days).
Published Date
1956-11-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume68
Issue
issue11
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
2075
End Page
2082
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/68/11/68_11_2075/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma