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Title Alternative
Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain
Author
Yamashita, Toru
Kamiya, Tatsushi
Inaba, Toshiki
Zhang, Hanzhe
Shang, Jingwei
Miyazaki, Kazunori
Katayama, Yasuo
Keywords
出血性梗塞 (hemorrhagic transformation)
tPA (tissue plasminogen activator)
MMP-9 (matrix metalloproteinase-9)
フリーラジカル (free radical)
エダラボン (edaravone)
Note
平成21年度岡山医学会賞(新見賞)受賞論文 (The 2009 Okayama Medical Association Award)
Published Date
2010-12-01
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume122
Issue
issue3
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
195
End Page
197
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Related Url
http://www.okayama-u.ac.jp/user/oma/
References
1) Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, et al. : Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med (2008) 359, 1317-1329.
2) Maier CM, Hsieh L, Crandall T, Narasimhan P, Chan PH : Evaluating therapeutic targets for reperfusion related brain hemorrhage. Ann Neurol (2006) 59, 929-938.
3) Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA : Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab (2007) 27, 697-709.
4) Lees KR, Zivin JA, Ashwood T, Davalos A, Davis SM, Diener HC, Grotta J, Lyden P, Shuaib A, Hardemark HG, Wasiewski WW : NXY-059 for acute ischemic stroke. N Engl J Med (2006) 354, 588-600.
5) Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, Diener HC, Ashwood T, Wasiewski WW, Emeribe U : NXY-059 for the treatment of acute ischemic stroke. N Engl J Med (2007) 357, 562-571.
6) Kuroda S, Tsuchidate R, Smith ML, Maples KR, Siesjo BK : Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemiain the rat. J Cereb Blood Flow Metab (1999) 19, 778-787.
7) Yamamoto Y, Kuwahara T, Watanabe K, Watanabe K : Antioxidant activity of 3-methyl-l-phenyl-2-pyrazolin-5-one. Redox Rep (1996) 2, 333-338.
language
日本語
Copyright Holders
Copyright (c) 2010 岡山医学会
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publisher
Refereed
True
DOI
Eprints Journal Name
joma