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ID 14007
Eprint ID
14007
FullText URL
Thumnail 105_217.pdf 496 KB
Title Alternative
The effects of MCI-186 for ischemic-reperfusion injury during cardiopulumonary bypass
Author
Takeo, Masahiko
Abstract
To determine the efficacy of MCI-186, a novel free radical scavenger, in ischemia-reperfusion injury during cardiopulumonary bypass (CPB), the following experimental model was applied. Twenty-one mongrel dogs were subjected to 120 minutes of hypothermic global ischemia by aortic cross clamping with intermittent administration of a cardioplegic solution followed by 60 minutes reperfusion. They were assingend to three groups : group A(n=7), no drug was administerd before reperfusion ; group B(n=7), 1ml/kg of physiological saline was administered by bolus injection through the aortic root just before reprefusion ; group C(n=7), MCI-186 (3mg/ml/kg) dissolved in physiological saline was administered in the same manner as group B. Cardiac function (left ventricular systolic pressure, cardiac output, left ventricular maximum dP/dt) after 60 minutes reperfusion expressed as as percent recovery of pre-ischemic state was superior in group C than in groups A and B. Release of lipidperoxide assayed by the TBA method as the difference between coronary artery and sinus were suppressed in the early phase of reperfusion in group C. Myocardial water content after 60 minutes reperfusion was also less in group C than in group A and B. These findings suggest that administration of MCI-186 before reprefusion after ischemia is effective in protecting the heart from ischemia-reperfusion injury.
Keywords
MCI-186
再灌流障害
free radical
心筋保護
体外循環
Published Date
1993-02-27
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume105
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
217
End Page
226
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/105/1-2/105_1-2_217/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma