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ID 16925
Eprint ID
16925
FullText URL
Thumnail 94_931.pdf 3.68 MB
Title Alternative
Myocardial protection by different cold cardioplegic solutions
Author
Fujisawa, Reisuke
Abstract
Efficacy of three different solutions for myocardial protection was determined in dogs after 120 minute ischemia. In group I cold cardioplegia and topical hypothermia were performed with Ringer's solution in 9 dogs. Cold Ringer's solution, which was modified to contain potassium at 30 mEq/1 and sorbitol at 401 mOsm/1, was used in group Ⅱ (6 dogs). In 11 dogs (group Ⅲ) Collins solution (K: 115 mEq/1, 467 mOsm) was employed. The parameters measured included myocardial cyclic AMP, myocardial adenocine triphosphate, blood lactate, blood pyrvate, blood glucose, blood NEFA and O2 consumption. Results obtained were as follows: 1. Resuscitation rate was highest in group Ⅱ, being 100%, and lowest in group I, 11%. It was 45% in group Ⅲ. 2. Myocardial adenosine triphosphate decreased least in group Ⅱ (3.83μmol/g) and most in group I (2.18μmol/g). 3. There were no statistically significant inter-group differences in the other parameters. It was concluded that the best solution for myocardial protection was the modified Ringer's solution in group Ⅱ because the resuscitation rate was the best of the 3 groups. It was also noted that the resuscitation rate coincided well with the concentration of ATP in the myocardium. The Collins solution was suitable for stopping cardiac action, but not suitable for coronary perfusate because of a high potassium concentration which injured the myocardium. Cold Ringer's solution was effective in myocardial protection only by cooling the heart, not by its own protective action.
Keywords
心筋保護法
cyclic AMP
ATP
Published Date
1982-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume94
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
931
End Page
942
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/94/9-10/94_9-10_931/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma