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ID 48138
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Title Alternative
Pathological complete response of advanced gastric cancer with pyloric stenosis to neoadjuvant S-1/CDDP chemotherapy: A case report
Author
Nishizaki, Masahiko
Fujiwara, Yasuhiro
Chouda, Yasuhiro
Kanazawa, Takashi
Ninomiya, Motoki
Fujiwara, Toshiyoshi ORCID Kakenhi
Abstract
A 59-year-old man with epigastric discomfort and anorexia was referred to our hospital. Endoscopy revealed a type 3 advanced gastric cancer with pyloric stenosis diagnosed as a poorly differentiated adenocarcinoma in the biopsy specimens. A gastrojejunal bypass operation was performed because of direct invasion to the pancreas. The patient was treated by three courses of neoadjuvant chemotherapy with S-1/CDDP. Follow-up abdominal CT scan revealed that the primary tumor had become smaller, suggesting that a partial response had been achieved. Distal gastrectomy with D2 lymphadenectomy was performed. The histopathological examination showed no residual cancer cells in the primary lesion or dissected lymph nodes. Final chemotherapy efficacy was evaluated as Grade 3. The patient was treated with S-1 for one year after the gastrectomy and lymphadenectomy and has been followed up for 18 months without evidence of recurrence.
Keywords
幽門狭窄 (pyloric stenosis)
進行胃癌 (advanced gastric cancer)
S-1/CDDP
術前化学療法 (neoadjuvant chemotherapy)
組織学的CR (pathological CR)
Note
症例報告(Case Report)
Published Date
2012-04-01
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume124
Issue
issue1
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
63
End Page
66
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright (c) 2012 岡山医学会
File Version
publisher
Refereed
True
DOI
Eprints Journal Name
joma