Author Tanimoto, Fumiaki|
Published Date 2010-03-25
Publication Title
Content Type Thesis or Dissertation
JaLCDOI 10.18926/fest/11444
Title Alternative Synthesis of Novel Temperature-responsive Polymer Gel of Poly(aspartic acid)s
FullText URL 011_103_106.pdf
Author Uehara, Hiroki| Tanimoto, Fumiaki| Kitamura, Yoshiro| Yoshizawa, Hidekazu|
Abstract Recently, thermo-responsive polymer gels have been studied in various research fields such as drug delivery system. One of represetative thermo-responsive polymer gels is poly(N-isopropylacrylamide) gel (PNIPAAm) that has a rapid and reversible volume phase transition. However, PNIPAAm is not biodegradable, resulting in limitation of its use in medical fields. Novel thermo-responsive polymer gel was prepared by closslinking of isopropylamine modified poly(succinimide) (IPA-PSI) (Poly[α,β -(DL-aspartate isopropyl amide)-co-(succinimide)]) with hexamethylenediamine. Because of peptide bonds in backbone, therefore, it is expected to possess biodegradability and biocompatibility. These gels changed their volume in response to change of environment such as temperature, pH and concentration of salt in water. Crosslinkage density and substitution degree of IPA-PSI affected volume phase transition bahavior of the gel.
Keywords Thermo-responsive polymer gel Biodegradable polymer Poly(aspartic acid) Lower Critical Solution Temperature(LCST) Drug delivery system(DDS)
Publication Title 岡山大学環境理工学部研究報告
Published Date 2006-03-15
Volume volume11
Issue issue1
Start Page 103
End Page 106
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002313620