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ID 14238
Eprint ID
14238
FullText URL
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Title Alternative
Regulation of transferrin receptor (TfR) expression on erythroblasts from patients with myelodysplastic syndrome Part 1. Influence of cell maturation, hemoglobin concentration and stainable iron granules on TfR expression
Author
Tsuyuno, Ritsurou
Abstract
Erythroblasts (EBLs) as well as thrombocytes and myelocytes show changes in patients with myelodysplastic syndrome (MDS). The changes include increse in sideroblasts and maturation delay. Expression of the transferrin receptor (TfR) has been known to correlate with stainable iron and cell maturation. To clarify whether the regulation mechanism of TfR on bone marrow EBLs is altered in MDS and acute leukemia (AL), TfR expression on EBL from MDS and AL were measured in individual cells as well as cell morphology, stainable iron granules (SIGs) in EBLs and cellular hemoglobin content using the morphometric method established in our laboratory. Generally, the number of TfR and density of TfR on EBLs decreased along with cell maturation. The density of TfR was negatively correlated with hemoglobin concentration (r=-0.76), but SIGs showed no significant correlation with TfR density. In a patint with RARS, there was no difference in TfR density between ringed and non-ringed sideroblasts. By contrast, in a patient with AL, the TfR density of EBLs with morphological changes in nucleus was lower than that of normal EBLs. These findings suggest that the regulation mechanism of TfR in MDS was similar to normal subjects in cell maturation, hemogulobin concentration and SIGs, leaving the question why EBLs in MDS contain numerous SIGs in future.
Keywords
transferrin receptor
hemoglobin
stainable iron granule
myelodysplastic syndrome
acute leukemia
Note
原著
Published Date
1991-08
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume103
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
869
End Page
877
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
http://www.journalarchive.jst.go.jp/japanese/jnlabstract_ja.php?cdjournal=joma1947&cdvol=103&noissue=7-8&startpage=869
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma