Author Kagawa, Shunsuke|
Published Date 1987-06-30
Publication Title 岡山医学会雑誌
Volume volume99
Issue issue5-6
Content Type Journal Article
Author Kagawa, Shunsuke|
Published Date 1987-06-30
Publication Title 岡山医学会雑誌
Volume volume99
Issue issue5-6
Content Type Journal Article
Author 香川 俊輔|
Published Date 1997-09-30
Publication Title
Content Type Thesis or Dissertation
Author Umeoka, Tatsuo| Kawashima, Takeshi| Kagawa, Shunsuke| Teraishi, Fuminori| Taki, Masaki| Nishizaki, Masahiko| Kyo, Satoru| Nagai, Katsuyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi|
Published Date 2004-09-01
Publication Title Cancer Research
Volume volume64
Issue issue17
Content Type Journal Article
Author Teraishi, Fuminori| Kagawa, Shunsuke| Watanabe, Takanori| Tango, Yasuhisa| Kawashima, Takeshi| Umeoka, Tatsuo| Nisizaki, Masahiko| Tanaka, Noriaki| Fujiwara, Toshiyoshi|
Published Date 2005-08-01
Publication Title FEBS Letters
Volume volume579
Issue issue19
Content Type Journal Article
FullText URL 118_9.pdf
Author 梅岡 達生| 川嶋 健| 香川 俊輔| 寺石 文則| 滝 正樹| 京 哲| 永井 勝幸| 浦田 泰生| 田中 紀章| 藤原 俊義|
Keywords GFP アデノウイルス テロメラーゼ 増幅 遺伝子治療
Publication Title 岡山医学会雑誌
Published Date 2006-05-01
Volume volume118
Issue issue1
Start Page 9
End Page 15
ISSN 0030-1558
language 日本語
Copyright Holders Copyright© 岡山医学会
File Version publisher
DOI 10.4044/joma1947.118.1_9
NAID 10017417061
Title Alternative In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus
FullText URL 120_01_013_021.pdf
Author Kishimoto, Hiroyuki| Kojima, Toru| Watanabe, Yuichi| Kagawa, Shunsuke| Fujiwara, Toshiya| Uno, Futoshi| Teraishi, Fuminori| Kyo, Satoru| Mizuguchi, Hiroyuki| Hashimoto, Yuuri| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi|
Keywords GFP アデノウイルス ヒトテロメラーゼ逆転写酵素
Publication Title 岡山医学会雑誌
Published Date 2008-05-01
Volume volume120
Issue issue1
Start Page 13
End Page 21
ISSN 00301558
language 日本語
Copyright Holders 岡山医学会
File Version publisher
DOI 10.4044/joma.120.13
NAID 10024170197
Author Endo, Yoshikatsu| Sakai, Ryo| Ouchi, Masaaki| Onimatsu, Hideki| Hioki, Masayoshi| Kagawa, Shunsuke| Uno, Futoshi| Watanabe, Yuichi| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi|
Published Date 2008-12-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue3
Content Type Journal Article
Author Kojima, Toru| Hashimoto, Yuuri| Watanabe, Yuichi| Kagawa, Shunsuke| Uno, Futoshi| Kuroda, Shinji| Tazawa, Hiroshi| Kyo, Satoru| Mizuguchi, Hiroyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi|
Published Date 2009-10-01
Publication Title The Journal of Clinical Investigation
Volume volume119
Issue issue10
Content Type Journal Article
Author Kojima, Toru| Hashimoto, Yuuri| Kagawa, Shunsuke| Tanaka, Noriaki| Urata, Yasuo| Fujiwara, Toshiyoshi|
Published Date 2010-12-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue3
Content Type Journal Article
Author Kuroda, Shinji| Fujiwara, Toshiya| Shirakawa, Yasuhiro| Yamasaki, Yasumoto| Yano, Syuya| Uno, Futoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Watanabe, Yuichi| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2011-08-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue2
Content Type Journal Article
Author Hashimoto, Yuuri| Tazawa, Hiroshi| Teraishi, Fuminori| Kojima, Toru| Watanabe, Yuichi| Uno, Futoshi| Yano, Shuya| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2012-06-15
Publication Title PLoS ONE
Volume volume7
Issue issue6
Content Type Journal Article
Author Sasaki, Tsuyoshi| Tazawa, Hiroshi| Hasei, Jo| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Yano, Shuya| Yoshida, Ryosuke| Uno, Futoshi| Kagawa, Shunsuke| Morimoto, Yuki| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Yoshida, Ryosuke| Tazawa, Hiroshi| Hashimoto, Yuuri| Yano, Shuya| Onishi, Teppei| Sasaki, Tsuyoshi| Shirakawa, Yasuhiro| Kishimoto, Hiroyuki| Uno, Futoshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2012-11
Publication Title Cancer Immunology, Immunotherapy
Volume volume61
Issue issue11
Content Type Journal Article
Author Hasei, Joe| Sasaki, Tsuyoshi| Tazawa, Hiroshi| Osaki, Shuhei| Yamakawa, Yasuaki| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Onishi, Teppei| Uno, Futoshi| Kagawa, Shunsuke| Urata, Yasuo| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Published Date 2013-03
Publication Title Molecular Cancer Therapeutics
Volume volume12
Issue issue3
Content Type Journal Article
Author Kojima, Toru| Watanabe, Yuichi| Hashimoto, Yuuri| Kuroda, Shinji| Yamasaki, Yasumoto| Yano, Shuya| Tazawa, Hiroshi| Uno, Futoshi| Kagawa, Shunsuke| Tanaka, Noriaki| Urata, Yasuo| Fujiwara, Toshiyoshi|
Published Date 2013-04-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/52006
FullText URL 67_6_333.pdf
Author Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.
Keywords oncolytic adenovirus autophagy E2F1 microRNA
Amo Type Review
Published Date 2013-12
Publication Title Acta Medica Okayama
Volume volume67
Issue issue6
Publisher Okayama University Medical School
Start Page 333
End Page 342
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24356717
Web of Sience KeyUT 000328915700001
Author Yano, Shuya| Tazawa, Hiroshi| Hashimoto, Yuuri| Shirakawa, Yasuhiro| Kuroda, Shinji| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Uno, Futoshi| Nagasaka, Takeshi| Urata, Yasuo| Kagawa, Shunsuke| Hoffman, Robert M.| Fujiwara, Toshiyoshi|
Published Date 2013-12-01
Publication Title Clinical Cancer Research
Volume volume19
Issue issue23
Content Type Journal Article
Author Tazawa, Hiroshi| Yano, Syuya| Yoshida, Ryosuke| Yamasaki, Yasumoto| Sasaki, Tsuyoshi| Hashimoto, Yuuri| Kuroda, Shinji| Ouchi, Masaaki| Onishi, Teppei| Uno, Futoshi| Kagawa, Syunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
Content Type Journal Article
Author Shigeyasu, Kunitoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Mori, Yoshiko| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Kuroda, Shinji| Urata, Yasuo| Goel, Ajay| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2014-05-28
Publication Title Gut
Content Type Journal Article