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ID 18251
Eprint ID
18251
FullText URL
Thumnail 77_711.pdf 330 KB
Title Alternative
Corticoid Metabolism in the Body: Correlation Pattern of Blood and Urine Corticoids in Psychiatric Patients
Author
Kohsaka, Mutsutoshi
Kobayashi, Junzo
Tsuji, Harunori
Izumiya, Kazunori
Nagao, Takashi
Fujiwara, Tsunehiro
Kikui, Shigeru
Abstract
To investigate the corticoid metabolism In Vivo of endogenous psychosis, authors have studied the relationship between urinary and serum corticoid patterns. Twenty four hour urine and blood samples were taken from 17 cases of both sexes of schizophrenic patients, 17 cases from both sexes of depressed patients, 17 cases from both sexes of normal control persons, 11 cases of right and left lobotomized chronic schizophsenic patients and 12 cases from both sexes of patients with pituitary tumors, pituitary cysts, craniopharyngeomas, disturbances in hypothalamus and so on. The urinary 17-KS were measured by a modified method of Koch and Holtorff and 17-OHCS were measured by Silber-Porter and Bongiovanni. Bacterial β Glucuronidase was used in hydrolysis. The results were as follows: 1. Free 17-OHCS in the urine and the serum were increased in schizophrenic and depressed patients in aggravating situations without exception. 2. Urinary 17-KS were decreased in aggravating situations in both schizophrenic and depressed patients. 3. The decrease of urinary 17-KS was significant in the male but not in the female. 4. High serum 17-CHCS levels were followed by high urine 17-OHCS values; in other words the values moved parallel in psychotic patients. 5. The value of conjugated 17-OHCS over free 17-OHCS (C/F) in the urine and blood always decreased in schizophrenic and depressed patients. 6. The ratios of urinary 17-KS over free serum 17-OHCS, and urinary total 17-OHCS over free serum 17-OHCS showed significant relationships in both schizophrenic and depressed patients; these ratios are decreased in an aghravating situation. 7. The frontal lobe plays a role in urinary 17-KS excretion. It should be emphasized that separating the frontal lobe from the thalamus or hypothalamus area will cause an increase in urinary 17-KS excretion. 8. Urinary or serum 17-OHCS values du not move in parallel to urinary 17-KS but rather in a reverse manner in psychotic patients.
Published Date
1965-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume77
Issue
issue4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
711
End Page
716
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/77/4/77_4_711/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma