Title Alternative Synthetic studies of ancistrocladinium A and B, antileishmanial compounds isolated from a Congolese Ancistrocladus Species
FullText URL srfa_108_001_004.pdf
Author Kiyota, Hiromasa| Saito, Akihito| Takai, Momoko| Kuwahara, Shigefumi|
Abstract Synthetic studies of ancistrocladinium A and B, antileishmanial compounds isolated from a Congolese Ancistrocladus sp., are described. Buchwald‒Hartwig coupling reaction between the dihydroisoquinoline and the naphthyl triflate failed. The main framework of ancistrocladinium A was constructed by 1,2‒addition of the amine to the naphthoquinone in the presence of celium trichloride as a catalyst. On the other hand, 1,4‒addition of the amine to the naphthoquinone proceeded without catalyst to form the framework of B. These products will be valuable leads for antileishmanial agents.
Keywords ancistrocladinium A and B synthetic studies leishmania, Ancistrocladus isoquinoline
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2019-02-01
Volume volume108
Start Page 1
End Page 4
ISSN 2186-7755
language 日本語
File Version publisher