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ID 30966
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Author
Wang, Jichun
Luo, Enjie
Hirai, Makoto
Arai, Meiji
Abdul Manand, Encik Abdul Salim
Isa, Zaleha Mohamed
Hidayah, Noor Ishak
Matsuoka, Hiroyuki
Abstract

The Malaysian people consist of several ethnic groups including the Malay, the Chinese, the Indian and the Orang Asli (aboriginal Malaysians). We collected blood samples from outpatients of 2 hospitals in the State of Selangor and identified 27 glucose-6-phosphate dehydrogenase (G6PD)-deficient subjects among these ethnic groups. In the Malay, G6PD Viangchan (871G>A, 1311C>T, IVS11 nt93T>C) and G6PD Mahidol (487G>A) types, which are common in Cambodia and Myanmar, respectively, were detected. The Malay also had both subtypes of G6PD Mediterranean:the Mediterranean subtype (563C>T, 1311C>T, IVS11 nt93T>C) and the Indo-Pakistan subtype (563C>T, 1311C, IVS11 nt93T). In Malaysians of Chinese background, G6PD Kaiping (1388G>A), G6PD Canton (1376G>T) and G6PD Gaohe (95A>G), which are common in China, were detected. Indian Malaysians possessed G6PD Mediterranean (Indo-Pakistan subtype) and G6PD Namoru (208T>C), a few cases of which had been reported in Vanuatu and many in India. Our findings indicate that G6PD Namoru occurs in India and flows to Malaysia up to Vanuatu. We also discovered 5 G6PD-deficient cases with 2 nucleotide substitutions of 1311C>T and IVS11 nt93T>C, but without amino-acid substitution in the G6PD molecule. These results indicate that the Malaysian people have incorporated many ancestors in terms of G6PD variants.

Keywords
Aborigine
Chinese
glucose-6-phosphate dehydrogenase
Indian
Malay
Amo Type
Original Article
Published Date
2008-10
Publication Title
Acta Medica Okayama
Volume
volume62
Issue
issue5
Publisher
Okayama University Medical School
Start Page
327
End Page
332
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT