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ID 17155
Eprint ID
17155
FullText URL
Thumnail 89_749.pdf 315 KB
Title Alternative
Effect of biscoclaurin alkaloids of the biomembrane system and its action mechanisms Part I. Inhibitory effects of cepharanthine on the K(+)-release after the injury to cell membrane
Author
Miyahara, Masanobu
Utsumi, Kozo
Sagiyama, Katsumi
Aono, Kaname
Abstract
Concerining the physiological properties possessed by the cell membrane, recently an attention has been called on various problems such as the cell recognition mechanism to begin with, and the mutual relationships among the intercellular communication mechanism, as well as the metabolism adjustment of membrane binding enzymes, aside from the compartmentation of substances. Essentially the physico-chemical properties of the membrane of cancer cell and proliferating cells are important in relation to the treatment of cancer. And attempts are being made to change the cell metabolism by artificially altering the physicochemical properties of the cell membrane. Cepharanthine, one of the biscoclaurin alkaloids, is known from olden days to possess a thanatophidia hemolytic property, but this property seems to bring about the change in the physico-chemical properties of the cell membrane, and it is interesting in the point that this substance may have a membrane modifying property. For these reasons, during the investigation on the actions of alkaloids on the cell membrane many interesting phenomena have been elucidated. This report presents the results recently obtained about the changes in physico-chemical properties of biological membrane by the treatment with cepharanthine. The obtained results were as follows. 1. Cepharanthine inhibits K(+)-release from red blood cells when these cells are treated with snake venom, phospholipase A, lysolecithine, lead acetate and hexane. But the alkaloid does not inhibit K(+)-release induced by ionophores, surface active agents and HVJ. 2. Cepharanthine inhibits the hyperpolalization of membrane potential induced by lead acetate or hexane. 3. Similar inhibitory effect of cholesterol on K(+)-release from the cells by the treatment with lead acetate is observed. 4. From these results it is suggested that the inhibitory action of cepharanthine on K(+)-release from cells is due to the action of decrease in membrane fluidity.
Published Date
1977-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume89
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
749
End Page
756
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/89/7-8/89_7-8_749/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma