JaLCDOI 10.18926/AMO/32717
FullText URL fulltext.pdf
Author Abe, Shinji|
Abstract <p>The effect of immunization with hamster fetal cells on the tumor induction by adnovirus type 12 was studied by in vivo and in vitro. The immunization with lO-day old fetal cells showed a recognizable inhibition on the tumor induction by adenovirus type 12. The inhibition was observed only in males but not in females. For the inhibition, immnization with 107 or more cells was required. The immunization with same dose of l2-day-old fetal cells were ineffective. The inoculation of the spleen cells from hamsters immunized with un· irradiated fetal cells strongly inhibited the adenovirus·12 onocogenesis. Membrane immunofluorescent test, however, failed to demonstrate the fetal antigens in any of adnovirus-12-induced tumor cells, SV40induced tumor cells and cells from spontaneous hamster lymphoma.</p>
Amo Type Article
Published Date 1974-06
Publication Title Acta Medica Okayama
Volume volume28
Issue issue3
Publisher Okayama University Medical School
Start Page 147
End Page 158
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4374047
NAID 120002311992
JaLCDOI 10.18926/AMO/32686
FullText URL fulltext.pdf
Author Abe, Shinji|
Abstract <p>The establishment of a hamster lymphoma cell line was attempted. Simple mincing and trypsinization of lymphoma tissue resulted in a high degree of cell degeneration. The ascitic tumor cells produced by intraperitoneal transplantation of lymphoma tissue gave a better result. These ascitic cells grew and were cultured successively in medium consisting of RPMI 1640 and 20% fetal calf serum. Cells were round and grew in suspension. Accelerated cell growth was observed one month after starting the culture. In the stained preparations, cells were lymphoblastic. Cells were transplantable into new-born hamsters and produced tumors, but not in young adult hamsters.</p>
Amo Type Article
Published Date 1974-08
Publication Title Acta Medica Okayama
Volume volume28
Issue issue4
Publisher Okayama University Medical School
Start Page 277
End Page 280
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4280237
NAID 120002311861