JaLCDOI 10.18926/AMO/32840
FullText URL fulltext.pdf
Author Abe, Asaki| Kawasoe, Chiaki| Kondo, Yasuhiro| Sato, Katsunori|
Abstract <p>Changes in norepinephrine-induced transient contractions in Ca2+-deficient solution were investigated in the aortic smooth muscles of diabetic ALS (alloxan-induced diabetes susceptible) mice. The transient contractions in diabetic mice were significantly larger than those in normal mice. The longer incubation of the muscle preparations in Ca2+-deficient solution made the transient contractions smaller, probably due to the leakage and decrease in norepinephrine-releasable stored Ca2+. The rate of this reduction in contraction was slower in diabetic mice. These results suggest that the leakage of intracellular stored Ca2+ caused by extracellular Ca2+ deficiency is attenuated in diabetic mice, contributing to enhanced norepinephrine-induced transient contractions.</p>
Keywords diabetes mellitus vascular smooth muscle norepinephrine
Amo Type Article
Published Date 2003-02
Publication Title Acta Medica Okayama
Volume volume57
Issue issue1
Publisher Okayama University Medical School
Start Page 45
End Page 48
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12765224
Web of Science KeyUT 000181198200007
Author Nagato, Kumiko| Abe, Asaki| Narabara, Kiyoaki| Kondo, Yasuhiro|
Published Date 2009-02
Publication Title 岡山大学農学部学術報告
Volume volume98
Issue issue1
Content Type Departmental Bulletin Paper
Author Kondo, Yasuhiro| Honjo, Sachika| Ohtsuki, Kazumasa| Abe, Asaki|
Published Date 2004-02
Publication Title 岡山大学農学部学術報告
Volume volume93
Issue issue1
Content Type Departmental Bulletin Paper
Author Han, Song| Abe, Asaki| Narahara, Kiyoaki| Kondo, Yasuhiro|
Published Date 2007-02
Publication Title 岡山大学農学部学術報告
Volume volume96
Issue issue1
Content Type Departmental Bulletin Paper