FullText URL EBioMedicine_2017_154.pdf
Author Kunisada, Yuki| Eikawa, Shingo| Tomonobu, Nahoko| Domae, Shohei| Uehara, Takenori| Hori, Shohei| Furusawa, Yukihiro| Hase, Koji| Sasaki, Akira| Udono, Heiichiro|
Keywords Glycolysis Regulatory T cell (Treg) Tumor immunity Tumor microenvironment mTOR
Published Date 2017-10-16
Publication Title EBioMedicine
Volume volume25
Publisher Elsevier Science
Start Page 154
End Page 164
ISSN 23523964
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2017 The Authors.
File Version publisher
PubMed ID 29066174
DOI 10.1016/j.ebiom.2017.10.009
Web of Science KeyUT 000417440500026
Related Url isVersionOf https://doi.org/10.1016/j.ebiom.2017.10.009
JaLCDOI 10.18926/AMO/55204
FullText URL 71_3_219.pdf
Author Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira|
Abstract  Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
Keywords oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry
Amo Type Original Article
Published Date 2017-06
Publication Title Acta Medica Okayama
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 219
End Page 226
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655941