FullText URL fulltext.pdf
Author Yamamoto, Takahiro| Fujimura, Atsushi| Wei, Fan-Yan| Shinojima, Naoki| Kuroda, Jun-Ichiro| Mukasa, Akitake| Tomizawa, Kazuhito|
Published Date 2019-11-22
Publication Title iScience
Volume volume21
Publisher Cell Press
Start Page 42
End Page 56
ISSN 2589-0042
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Author(s).
File Version publisher
PubMed ID 31654853
DOI 10.1016/j.isci.2019.10.012
Web of Science KeyUT 000498899800004
Related Url isVersionOf https://doi.org/10.1016/j.isci.2019.10.012
Author Masumoto, Toshio| Suzuki, Koichiro| Ohmori, Iori| Michiue, Hiroyuki| Tomizawa, Kazuhito| Fujimura, Atsushi| Nishiki, Tei-ichi| Matsui, Hideki|
Published Date 2012-01
Publication Title Molecular and Cellular Neuroscience
Volume volume49
Issue issue1
Content Type Journal Article
Author Fujimura, Atsushi| Michiue, Hiroyuki| Nishiki, Tei-ichi| Ohmori, Iori| Wei, Fanyan| Matsui, Hideki| Tomizawa, Kazuhito|
Published Date 2011-05-14
Publication Title PLoS ONE
Volume volume6
Issue issue3
Content Type Journal Article
Author Candan, Gerile| Michiue, Hiroyuki| Ishikawa, Sanae| Fujimura, Atsushi| Hayashi, Keiichiro| Uneda, Atsuhito| Mori, Akiko| Ohmori, Iori| Nishiki, Tei-ichi| Matsui, Hideki| Tomizawa, Kazuhito|
Published Date 2012-09
Publication Title Biomaterials
Volume volume33
Issue issue27
Content Type Journal Article
JaLCDOI 10.18926/AMO/43824
FullText URL 65_1_1.pdf
Author Han, Xiao-Jian| Tomizawa, Kazuhito| Fujimura, Atsushi| Ohmori, Iori| Nishiki, Tei-ichi| Matsushita, Masayuki| Matsui, Hideki|
Abstract Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent studies, several large GTPases have been identified as key molecular factors in mitochondrial fission and fusion. Moreover, the posttranslational modifications of these large GTPases, including phosphorylation, ubiquitination and SUMOylation, have been shown to be involved in the regulation of mitochondrial dynamics. Neurons are particularly sensitive and vulnerable to any abnormalities in mitochondrial dynamics, due to their large energy demand and long extended processes. Emerging evidences have thus indicated a strong linkage between mitochondria and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease. In this review, we will describe the regulation of mitochondrial dynamics and its role in neurodegenerative diseases.
Keywords mitochondria phosphorylation ubiquitination SUMOylation neurodegeneration
Amo Type Review
Published Date 2011-02
Publication Title Acta Medica Okayama
Volume volume65
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 10
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2011 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 21339790
Web of Science KeyUT 000287620500001