JaLCDOI 10.18926/AMO/54192
FullText URL 70_2_131.pdf
Author Ohuchi, Hideyo| Taniguchi, Kaori| Miyaishi, Satoru| Kono, Hitomi| Fujita, Hirofumi| Bando, Tetsuya| Fuchizawa, Chiharu| Ohtani, Yuko| Ohtani, Osamu|
Abstract Human congenital anomalies provide information that contributes to the understanding of developmental mechanisms. Here we report bilateral optic nerve aplasia (ONA) with microphthalmia in the autopsy of the cadaver of a 70-year-old Japanese female. The gross anatomical inspection of the brain showed a cotton thread-like cord in the presumed location of the optic nerve tract or chiasm. Histologically, no neural retina, optic nerve bundle or retinal central vessels were formed in the eye globe, and the retinal pigment cells formed rosettes. The cornea, iris, and lens were also histologically abnormal. Immunohistochemically, no retinal cells expressed beta III tubulin, and Pax6-immunoreactive cells were present in the ciliary non-pigmented epithelial cells. This case of ONA could be attributed to the agenesis of retinal projection neurons as a sequel to the disruption of neural retina development. The neural retina formation would coordinate the proper development of ocular tissues.
Keywords eye development human congenital anomalies optic nerve aplasia microphthalmia neural retina
Amo Type Case Reports
Published Date 2016-04
Publication Title Acta Medica Okayama
Volume volume70
Issue issue2
Publisher Okayama University Medical School
Start Page 131
End Page 137
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27094838
Web of Science KeyUT 000377626300008